Table 3.

Association of urinary uromodulin-to-creatinine ratio with postoperative peak serum creatinine

Uromodulin-to-Creatinine RatioMean (SD) Peak CreatinineDifference in Mean Peak Serum Creatinine (95% CI)Model 1 Difference in Mean Peak Serum Creatinine (95% CI)Model 2 Difference in Mean Peak Serum Creatinine (95% CI)
Per 1 SDa1.3 (0.5)0.11 (0.04 to 0.18), P=0.0020.10 (0.03 to 0.17), P=0.0030.07 (0.02 to 0.13), P<0.01
Quartile 1 (0.8–4.1), μg/g1.4 (0.5)0.27 (0.08 to 0.47)0.23 (0.05 to 0.42)0.14 (−0.01 to 0.29)
Quartile 2 (4.2–9.9), μg/g1.4 (0.7)0.35 (0.16 to 0.55)0.34 (0.16 to 0.53)0.23 (0.08 to 0.38)
Quartile 3 (10.0–22.8), μg/g1.3 (0.5)0.21 (0.02 to 0.40)0.17 (−0.01 to 0.36)0.06 (−0.09 to 0.21)
Quartile 4 (22.9–93.7), μg/g1.1 (0.3)000
Trend P value0.002<0.010.01
  • Model 1: adjusted for age, sex, and race. Model 2: model 1 plus eGFR, diabetes, heart failure, left ventricular ejection fraction, elective versus nonelective surgery, valvular versus other cardiac surgery, and urine albumin-to-creatinine ratio. 95% CI, 95% confidence interval.

  • a 1 SD=14.8 μg/g.