Table 3.

Associations of left ventricular mass index quartiles with death in the Chronic Renal Insufficiency Cohort participants without heart failure

LVMI Q (g/m2.7)N (Events)N (Participants)RateHR (95% CI)
Model 1Model 2Model 3
All
 Q1 (<41.3)4664110.8ReferenceReferenceReference
 Q2 (41.3 to <48.5)6764316.01.21 (0.82 to 1.79)1.19 (0.8 to 1.76)1.19 (0.79 to 1.78)
 Q3 (48.5 to <57.5)11064227.41.86 (1.27 to 2.71)1.8 (1.23 to 2.64)1.7 (1.14 to 2.52)
 Q4 (≥57.5)15964141.82.22 (1.49 to 3.32)2.14 (1.43 to 3.21)1.86 (1.22 to 2.85)
 Linear trend P value<0.001<0.0010.003
Men
 Q1 (<41.7)2634511.4ReferenceReferenceReference
 Q2 (41.7 to <48.8)4134418.61.31 (0.78 to 2.18)1.27 (0.76 to 2.12)1.25 (0.74 to 2.11)
 Q3 (48.8 to <57.4)7034532.71.88 (1.15 to 3.08)1.83 (1.11 to 2.99)1.69 (1.02 to 2.8)
 Q4 (≥57.4)8834443.82.06 (1.21 to 3.5)1.98 (1.17 to 3.36)1.7 (0.98 to 2.95)
 Linear trend P value0.003<0.010.07
Women
 Q1 (<40.8)182979.1ReferenceReferenceReference
 Q2 (40.8 to <47.9)2529712.61.19 (0.63 to 2.24)1.2 (0.62 to 2.3)1.27 (0.64 to 2.51)
 Q3 (47.9 to <57.7)4329822.92.23 (1.21 to 4.13)2.14 (1.13 to 4.06)2.21 (1.12 to 4.36)
 Q4 (≥57.7)7129739.53.33 (1.74 to 6.36)3.2 (1.63 to 6.29)3.08 (1.5 to 6.32)
 Linear trend P value<0.0010.001<0.01
  • Model 1: age, race, study site, diabetes, cardiovascular disease, tobacco, alcohol use, log(24-hour proteinuria), eGFR (Chronic Renal Insufficiency Cohort equation), systolic BP, diastolic BP, body mass index, LDL, HDL, aldosterone antagonists, angiotensin–converting enzyme inhibitors, angiotensin receptor blockers, diuretics, β-blockers, phosphate, and hemoglobin. Model 2: model 1 plus log(parathyroid hormone), log(fibroblast growth factor-23), aspirin, and statin. Model 3: model 2 plus log(B–type natriuretic peptide) and log(high–sensitivity troponin T). LVMI, left ventricular mass index; Q, quartile; HR, hazard ratio; 95% CI, 95% confidence interval.