Table 2.

Association of urinary uromodulin-to-creatinine ratio and postoperative AKI

Urinary Uromodulin-to-Creatinine RatioNo. of Events (%)Unadjusted OR (95% CI)Model 1 OR (95% CI)Model 2 OR (95% CI)
AKI
 Per 1 SDa64 (29.4)1.49 (1.04 to 2.13), P=0.031.53 (1.06 to 2.20), P=0.021.43 (0.99 to 2.07), P=0.06
 Quartile 1 (0.8–4.1), μg/g20 (37.0)2.94 (1.19 to 7.26)2.98 (1.19 to 7.46)2.43 (0.91 to 6.48)
 Quartile 2 (4.2–9.9), μg/g18 (32.7)2.43 (0.98 to 6.05)2.70 (1.06 to 6.86)2.21 (0.81 to 6.01)
 Quartile 3 (10.0–22.8), μg/g17 (30.9)2.24 (0.89 to 5.59)2.10 (0.84 to 5.26)1.69 (0.64 to 4.48)
 Quartile 4 (22.9–93.7), μg/g9 (16.7)1.00 (reference)1.00 (reference)1.00 (reference)
 Trend P value0.020.020.06
Severe AKI
 Per 1 SDa8 (3.7)3.15 (0.71 to 13.96), P=0.132.68 (0.85 to 8.42), P=0.092.03 (0.80 to 5.17), P=0.14
 Below versus above medianb7 (87.5)7.41 (0.90 to 61.3), P=0.066.67 (1.22 to 36.30), P=0.034.03 (0.87 to 18.70), P=0.08
  • Model 1: adjusted for age, sex, and race. Model 2: model 1 plus eGFR, diabetes, heart failure, left ventricular ejection fraction, elective versus nonelective surgery, valvular versus other cardiac surgery, and urine albumin-to-creatinine ratio. OR, odds ratio; 95% CI, 95% confidence interval.

  • a 1 SD=14.8 μg/g.

  • b There was a total of eight events of severe AKI, of which seven (85%) occurred in the first two quartiles (below the median).