Table 1.

Characteristics of 30 boys and men with Dent disease at renal biopsy

Patient Study No.DemographicsClinical Features
Age at Kidney Biopsy, yrCountry of OriginRaceRelationship to Any Other PatientGenetically Confirmed Type of Dent DiseaseeGFR, ml/min per 1.73 m2Increased Urinary LMWPHypercalciuriaHistory of Kidney StonesRickets
11SpainWhite167YesYesNoYes
27United StatesWhite1117.9NDNDNoND
340United StatesWhite148.0YesNoNoND
411United StatesWhite199.04YesYesNoND
53CanadaWhite131.4NDNDNoNo
615United StatesWhite169.19NDNDYesNo
719UruguayWhite139.0YesNoNoNo
85EnglandWhite1110.57YesYesNoNo
98United StatesWhite163.7YesNDNoNo
1038EthiopiaOther (including two or more races)Not type 1 or 26.0YesNoYesNo
111.5United StatesAsian179.12YesYesNoND
124United StatesWhite190.47YesYesNoND
137United StatesBlackBrother to 14238.73YesYesNoND
147United StatesBlackBrother to 13281.7YesYesNoND
1511United StatesWhite157.3YesYesYesNo
1627United StatesWhiteBrother to 19120YesYesNoNo
177United StatesWhite1142.2YesYesNoND
185AlgeriaWhite164.1YesYesNoND
1921United StatesWhiteBrother to 16155.0NDYesNoNo
206United StatesWhite1171.28YesYesNDNo
2119EnglandWhite118NDYesNDYes
2212United StatesWhite176NDYesNoNo
237United StatesWhite179.5YesYesNoNo
245United StatesWhite170.03YesYesNoNo
2530United StatesWhite128.0YesNDNoNo
266ItalyWhite188YesNoNoYes
279ItalyWhite1114YesYesYesNo
2811ItalyWhite197YesYesNoNo
293ItalyWhite1NDYesNoNoNo
3048ItalyWhiteNot type 1 or 263YesYesYesNo
Overall7.5 (5, 19)86% White86% Dent disease 169 (44, 94)100%80%18%14%
  • Data for overall are presented as medians (25th, 75th percentiles) or percentages. Note that, for patients younger than 18 years of age, eGFR was calculated using the Schwartz formula (13). For patients older than 18 years of age, eGFR was calculated using the Modification of Diet in Renal Disease equation (14). LMWP, low molecular weight proteinuria; ND, not determined or not available.