Table 2.

Results of unadjusted analyses for all available covariates and study end points

VariableESRDAll-Cause MortalityNonfatal Cardiovascular Events
HR (95% CI)P ValueHR (95% CI)P ValueHR (95% CI)P Value
Age, per 5 yr0.90 (0.86 to 0.90)<0.0011.47 (1.40 to 1.54)<0.0011.02 (1.10 to 1.22)<0.001
Men0.94 (0.77 to 1.15)0.551.15 (1.05 to 1.25)0.0031.36 (0.94 to 1.97)0.10
Diabetes1.04 (0.84 to 1.28)0.731.71 (1.44 to 2.03)<0.0011.66 (1.17 to 2.35)<0.001
Smoker1.01 (0.83 to 1.22)0.951.77 (1.47 to 2.14)<0.0011.07 (0.75 to 1.54)0.69
Prior cardiovascular event0.79 (0.63 to 1.01)0.062.35 (1.98 to 2.78)<0.0014.41 (3.11 to 6.24)<0.001
Heart failure at baseline1.05 (0.92 to 1.19)0.462.69 (2.24 to 3.24)<0.0011.52 (1.26 to 1.83)<0.001
Mean systolic BP, per 5 mmHg1.05 (1.00 to 1.05)0.0021.05 (1.00 to 1.05)<0.011.00 (0.95 to 1.05)0.72
Baseline eGFR, per 5 ml/min per 1.73 m20.50 (0.44 to 0.53)<0.0010.86 (0.86 to 0.90)<0.0010.95 (0.90 to 0.95)0.02
Urinary protein excretion, per 0.1 g/24 h1.04 (1.04 to 1.05)<0.0011.01 (0.99 to 1.06)0.261.01 (0.99 to 1.03)0.49
Phosphate, per 0.5 mg/dl1.64 (1.57 to 1.70)<0.0011.16 (1.09 to 1.22)<0.0011.09 (0.98 to 1.20)0.11
Corrected calcium, per 0.5 mg/dl0.83 (0.75 to 0.92)<0.0010.99 (0.92 to 1.08)0.890.90 (0.76 to 1.06)0.21
Parathyroid hormone, per 10 pg/ml1.10 (1.00 to 1.10)<0.0011.00 (1.00 to 1.10)<0.0011.00 (1.00 to 1.10)0.004
Albumin, per 0.1 g/dl0.91 (0.89 to 0.93)<0.0010.91 (0.89 to 0.93)<0.0010.94 (0.90 to 0.97)0.001
Hemoglobin, per 1 g/dl0.66 (0.66 to 0.74)<0.0010.82 (0.74 to 0.82)<0.0010.90 (0.82 to 1.00)0.12
C-reactive protein, per 1 mg/L1.00 (0.99 to 1.01)0.811.01 (1.00 to 1.01)<0.0011.01 (0.99 to 1.01)0.07
Ln KIM-1, per 1 SD2.03 (1.86 to 2.21)<0.0011.33 (1.22 to 1.44)<0.0011.20 (1.01 to 1.43)0.03
Ln NGAL, per 1 SD3.50 (3.11 to 3.93)<0.0011.50 (1.36 to 1.64)<0.0011.16 (0.96 to 1.39)0.12
  • HR, hazard ratio; 95% CI, 95% confidence interval; Ln, natural logarithm; KIM-1, kidney injury molecule-1; NGAL, neutrophil gelatinase‚Äďassociated lipocalin.