Table 3.

Results of multivariate analysis showing association between variables and ESRD

VariableModel 1 (Baseline Covariates)Model 2 (Baseline Covariates Plus Biomarkers)
HR (95% CI)P ValueHR (95% CI)P Value
Age, per 5 yr0.86 (0.82 to 0.90)<0.0010.86 (0.82 to 0.86)<0.001
Mean systolic BP, per 5 mmHg1.05 (1.00 to 1.05)0.051.00 (0.95 to 1.05)0.39
Baseline eGFR, per 5 ml/min per 1.73 m20.56 (0.53 to 0.59)<0.0010.62 (0.56 to 0.66)<0.001
Urinary protein, per 0.1 g/24 h1.03 (1.02 to 1.04)<0.0011.03 (1.01 to 1.04)<0.001
Hemoglobin, per 1 g/dl0.90 (0.82 to 0.90)0.0020.90 (0.82 to 0.90)0.03
Albumin, per 0.1 g/dl0.99 (0.96 to 1.02)0.541.01 (0.98 to 1.04)0.70
Phosphate, per 0.5 mg/dl1.12 (1.06 to 1.18)<0.0011.01 (1.03 to 1.16)0.002
Corrected calcium, per 0.5 mg/dl1.01 (1.06 to 1.16)0.760.96 (0.89 to 1.05)0.41
Parathyroid hormone, per 10 pg/ml1.00 (1.00 to 1.10)<0.0011.00 (1.00 to 1.00)0.001
Ln KIM-1, per SD1.25 (1.10 to 1.43)<0.001
Ln NGAL, per SD1.35 (1.14 to 1.59)<0.001
c Statistic for model0.90 (0.89 to 0.92)0.91 (0.89 to 0.92)
  • HR, hazard ratio; 95% CI, 95% confidence interval; Ln, natural logarithm; KIM-1, kidney injury molecule-1; NGAL, neutrophil gelatinase‚Äďassociated lipocalin.