Table 2.

Renal histopathologic findings among 30 boys and men with Dent disease

Histopathologic FindingsValue
Glomerular findings
 Focal global glomerulosclerosis83.3% (25 of 30)
  Globally sclerotic glomeruli (median; 25%, 75%)9.5% (2.2, 24.3)
 FSGS6.6% (2 of 30)
 Focal segmental glomerular capillary collapse6.6% (2 of 30)
 Mild mesangial hypercellularity13.3% (4 of 30)
 Cellular crescent3.3% (1 of 30)
 Foot process effacement56.5% (13 of 23)
  Segmental100% (13 of 13)
  Mild92% (12 of 13)
Tubulointerstitial findings
 Focal interstitial fibrosis60% (18 of 30)
  Mild94.4% (17 of 18)
  Moderate to severe5.6% (1 of 18)
 Focal interstitial inflammation53.3% (16 of 30)
  Mild93.8% (15 of 16)
  Moderate to severe6.2% (1 of 16)
 Tubular damage70% (21 of 30)
 Nephrocalcinosis20% (6 of 30)
  • Data are presented as percentages (n of n) unless otherwise noted.