Table 4.

Factors contributing to the development of AKI

DescriptionAll PatientsMonotherapyCombination TherapyP Value
AKI events295105190
No. of events (%) with evaluable dataa290 (98.3)104 (99.0)186 (97.9)
Predisposing factorsb (%)
 Volume depletionc176 (60.7)59 (56.7)117 (62.9)0.30
 Diureticsc161 (55.5)61 (58.7)100 (53.8)0.42
 Acute gastrointestinal illnessc53 (18.3)14 (13.5)39 (21.0)0.11
 Medicationsc142 (49.0)56 (54.4)86 (46.2)0.21
 Iodinated radiocontrast mediac12 (4.1)5 (4.8)7 (3.8)0.67
 Aminoglycoside antibioticsc8 (2.8)3 (2.9)5 (2.7)0.92
 Vasopressorsc4 (1.4)2 (1.8)2 (1.0)0.55
 Urinary retentionc26 (9.0)14 (13.5)12 (6.5)0.05
  • a Percentages calculated on the basis of total number of AKI events.

  • b Totals exceed 100%, because patients may have had more than one contributing factor.

  • c Percentages calculated on the basis of number of AKI events with evaluable data.