Table 3.

Predictors of AKI

PredictoraUnivariate AnalysisMultivariate AnalysisStepwise Selection
HR95% CIP ValueHR95% CIP ValueHR95% CIP Value
Age, per yr0.99097 to 1.010.250.990.97 to 1.010.48
Race
 Black1.010.74 to 1.340.971.190.84 to 1.670.32
 Other0.630.26 to 1.550.320.590.24 to 1.450.25
UAE,b per ln unit1.421.24 to 1.62<0.0011.421.24 to 1.64<0.0011.421.24 to 1.64<0.001
eGFR, per 5 ml/min per 1.73 m20.920.88 to 0.99<0.0010.950.90 to 1.000.010.940.90 to 1.000.003
BP, per 1 mmHg
 Systolic0.990.98 to 1.000.140.990.98 to 1.000.150.990.98 to 1.000.03
 Diastolic0.990.98 to 1.000.110.990.97 to 1.010.27
BMI, per 1 kg/m21.021.00 to 1.040.031.010.99 to 1.040.16
CHF1.781.29 to 2.46<0.0011.641.16 to 2.31<0.011.641.19 to 2.270.003
CAD1.030.78 to 1.350.840.900.67 to 1.200.46
Retinopathy1.020.78 to 1.340.860.890.67 to 1.190.45
HbA1c, per 1%1.030.92 to 1.150.611.020.91 to 1.140.74
Diuretic use1.280.93 to 1.750.131.070.77 to 1.490.69
Serum potassium, per 1 mEq/L1.311.00 to 1.700.051.361.03 to 1.790.03
Combination therapy1.701.28 to 2.24<0.0011.631.23 to 2.16<0.0011.651.24 to 2.18<0.001
  • HR, hazard ratio; 95% CI, 95% confidence interval; UAE, urine albumin excretion; BMI, body mass index; CHF, history of congestive heart failure; CAD, history of coronary artery disease; HbA1c, hemoglobin A1c.

  • a All predictors on the basis of values at time of randomization.

  • b UAE natural log transformed.