Table 3.

Risk of all-cause mortality by HDL cholesterol deciles in eGFR category

HDL-C DecileMedian (IQR)All-Cause Mortality Hazard Ratio (95% Confidence Interval)
OveralleGFR≥15 to <30 ml/min per 1.73 m2eGFR≥30 to <45 ml/min per 1.73 m2eGFR≥45 to <60 ml/min per 1.73 m2eGFR≥60 to <90 ml/min per 1.73 m2eGFR≥90 ml/min per 1.73 m2
Decile 1 (low HDL-C)27.0 (24.0–28.0)1.001.001.001.001.001.00
Decile 232.0 (31.0–32.9)0.92 (0.91 to 0.93)0.92 (0.88 to 0.97)0.94 (0.92 to 0.97)0.90 (0.88 to 0.92)0.93 (0.91 to 0.94)0.92 (0.90 to 0.95)
Decile 334.0 (34.0–35.0)0.91 (0.90 to 0.93)0.93 (0.88 to 0.99)0.90 (0.87 to 0.93)0.92 (0.90 to 095)0.91 (0.89 to 0.93)0.92 (0.89 to 0.95)
Decile 437.0 (36.0–38.0)0.91 (0.90 to 0.92)0.91 (0.87 to 0.96)0.92 (0.89 to 0.95)0.89 (0.87. 0.91)0.91 (0.89 to 0.92)0.92 (0.89 to 0.94)
Decile 540.0 (39.0–41.0)0.90 (0.89 to 0.91)0.91 (0.86 to 0.96)0.94 (0.91 to 0.97)0.88 (0.86 to 0.90)0.89 (0.87 to 0.90)0.91 (0.89 to 0.94)
Decile 643.0 (42.0–44.0)0.90 (0.89 to 0.91)0.99 (0.94 to 1.05)0.89 (0.86 to 0.92)0.88 (0.86 to 0.90)0.90 (0.89 to 0.92)0.91 (0.88 to 0.94)
Decile 746.0 (45.0–47.0)0.91 (0.90 to 0.92)0.89 (0.84 to 0.96)0.92 (0.88 to 0.95)0.89 (0.86 to 0.91)0.91 (0.90 to 0.93)0.92 (0.89 to 0.95)
Decile 850.0 (48.9–51.0)0.92 (0.91 to 0.93)0.97 (0.91 to 1.03)0.91 (0.87 to 0.94)0.89 (0.86 to 0.91)0.91 (0.90 to 0.93)0.98 (0.95 to 1.01)
Decile 956.0 (54.0–58.0)0.94 (0.93 to 0.95)0.95 (0.89 to 1.02)0.95 (0.91 to 0.98)0.90 (0.88 to 093)0.93 (0.91 to 0.95)1.01 (0.98 to 1.04)
Decile 10 (high HDL-C)68.1 (64.0–77.0)1.09 (1.08 to 1.11)1.07 (1.00 to 1.15)0.99 (0.96 to 1.04)1.01 (0.98 to 1.04)1.08 (1.06 to 1.09)1.22 (1.18 to 1.25)
  • Models were adjusted for age, race, cancer, cerebrovascular accident, chronic lung disease, diabetes mellitus, dementia, hepatitis C, HIV, hypertension, body mass index, LDL cholesterol, triglycerides, serum albumin, angiotensin–converting enzyme inhibitor/angiotensin receptor blocker use, coronary artery disease, congestive heart failure, and peripheral artery disease. Models were additionally adjusted for eGFR, dialysis, kidney transplant, and statin use as time varying. IQR, interquartile range; HDL-C, HDL cholesterol.