Table 4.

Cox models (end point atherosclerotic event/all-cause mortality)

Exposure VariableModel 1Model 2Model 3Model 4
HR (95% CI)P ValueHR (95% CI)P ValueHR (95% CI)P ValueHR (95% CI)P Value
Continuous predictors
 Log NT-proBNP, pg/ml4.39 (3.36 to 5.74)<0.0013.68 (2.77 to 4.90)<0.0012.88 (2.05 to 4.04)<0.0012.91 (1.99 to 4.25)<0.001
 LVMI, g/m21.01 (1.01 to 1.02)<0.0011.01 (1.01 to 1.02)<0.0011.01 (1.00 to 1.01)0.021.00 (1.00 to 1.01)0.74
 LAVI, ml/m21.05 (1.03 to 1.06)<0.0011.03 (1.02 to 1.05)<0.0011.03 (1.01 to 1.04)<0.0011.01 (0.99 to 1.03)0.31
 E/e′1.16 (1.11 to 1.21)<0.0011.17 (1.11 to 1.24)<0.0011.12 (1.05 to 1.19)<0.0011.08 (1.01 to 1.14)0.02
Categorized predictors
 NT-proBNP<0.001<0.001<0.001<0.001
  Second tertilea2.11 (1.10 to 4.07)0.021.78 (0.91 to 3.48)0.091.76 (0.89 to 3.46)0.101.70 (0.86 to 3.37)0.12
  Third tertilea8.16 (4.55 to 14.64)<0.0015.90 (3.17 to 10.98)<0.0013.96 (2.03 to 7.72)<0.0013.64 (1.84 to 7.19)<0.001
 LVMI<0.001<0.010.070.38
  Second tertilea1.39 (0.83 to 2.33)0.221.05 (0.61 to 1.78)0.870.95 (0.56 to 1.62)0.860.86 (0.51 to 1.48)0.59
  Third tertilea2.82 (1.77 to 4.50)<0.0011.89 (1.16 to 3.09)0.011.52 (0.92 to 2.51)0.101.18 (0.71 to 1.98)0.52
 LAVI<0.0010.0030.020.27
  Second tertilea1.53 (0.88 to 2.64)0.131.21 (0.69 to 2.12)0.501.23 (0.71 to 2.15)0.461.10 (0.62 to 1.95)0.74
  Third tertilea3.28 (2.00 to 5.37)<0.0012.18 (1.30 to 3.65)0.0031.95 (1.17 to 3.25)0.011.48 (0.86 to 2.54)0.16
 E/e′<0.001<0.0010.050.29
  Second tertilea1.43 (0.81 to 2.53)0.221.24 (0.70 to 2.20)0.471.00 (0.56 to 1.81)0.990.95 (0.52 to 1.71)0.85
  Third tertilea3.43 (2.07 to 5.71)<0.0012.54 (1.49 to 4.34)<0.0011.66 (0.97 to 2.84)0.061.34 (0.78 to 2.31)0.30
 Systolic LV function
  Impaired (versus normal)2.70 (1.80 to 4.03)<0.0012.02 (1.34 to 3.05)<0.0011.75 (1.15 to 2.68)<0.011.36 (0.88 to 2.09)0.17
  • Model 1 is the univariable analysis. Model 2 is adjusted for age and sex. Model 3 is adjusted for age, sex, eGFR, diabetes mellitus, prevalent cardiovascular disease, smoking, diastolic BP, and cholesterol. Model 4 includes variables from model 3 and NT-proBNP (for all analyses with echocardiographic parameters as exposure variable) or systolic LV function (analyses with NT-proBNP as exposure variable). HR, hazard ratio; 95% CI, 95% confidence interval; NT-proBNP, amino–terminal probrain natriuretic peptide; LVMI, left ventricular mass index; LAVI, left atrial volume index; E/e′, diastolic left ventricular function.

  • a Reference is the first tertile.