Table 5.

Major bleeding risk in atrial fibrillation in patients with CKD treated with warfarin

StudyCountryDesignNAdjusted HR Major Bleeding (95% CI)
Banerjee et al., 2014 (9)FranceRetrospective5912 (2982 with eGFR<60 ml/min per 1.73 m2 and 1550 on warfarin)0.96 (0.55 to 1.67)
Carrero et al., 2014 (8)SwedenProspective24317 (5292 on warfarin)eGFR>30–60 ml/min per 1.73 m2: 1.08 (0.89 to 1.32)
eGFR>15–30 ml/min per 1.73 m2: 0.93 (0.60 to 1.44)
Olesen et al., 2012 (5)DenmarkRetrospective3587 (609 on warfarin)2.24 (2.10 to 2.38)
  • HR, hazard ratio; 95% CI, 95 % confidence interval.