Table 3.

Mean±SD 24-hour urine calcium, phosphate, potassium, sodium, and magnesium excretion in the dosing regimen study (4-day preplanned analysis)

Urine AnalytePatiromer Dosing Regimen
8.4 g Three Times per d12.6 g Two Times per d25.2 g One Time per d
uCa, mg
 Baseline143±82143±82143±82
 Treatment216±97209±97196±90a
 Change from baseline73±3966±3453±26a
uP, mg
 Baseline890±158890±158890±158
 Treatment733±99741±102793±103b,c
 Change from baseline−157±124−150±119−97±134b,c
uK, mg
 Baseline4450±3624450±3624450±362
 Treatment3010±4742916±3273012±446
 Change from baseline−1440±384−1534±295−1438±384
uNa, mg
 Baseline2869±4882869±4882869±488
 Treatment2288±2682442±3062323±247
 Change from baseline−581±536−428±603−546±693
uMg, mg
 Baseline134±37134±37134±37
 Treatment95±2391±23100±23
 Change from baseline−39±22−43±18−34±21
  • uCa, urine calcium; uP, urine phosphate; uK, urine potassium; uNa, urine sodium; uMg, urine magnesium.

  • a P=0.01 versus three times per day for pairwise comparison between regimens from t test.

  • b P<0.01 versus three times per day for pairwise comparison between regimens from t test.

  • c P=0.02 versus two times per day for pairwise comparison between regimens from t test.