Table 3.

Multivariable model of determinants of relapse rate between start of mycophenolate mofetil and first mycophenolic acid pharmacokinetic study (n=95 area under the concentration-time curves of mycophenolic acid in 95 patients)

ParameterNegative Binomial Model
RR95% CIP Value
Boys versus girls2.171.02 to 7.530.04
Age at INS per yr0.930.75 to 1.170.58
Time from INS to MMF per yr0.940.78 to 1.130.51
Previous immunomodulatory treatment versus none2.461.30 to 6.370.02
Concomitant prednisone dose, mg/m2 per d
 01 (reference)
 1–10 2.491.09 to 6.960.03
 >103.730.81 to 11.340.11
MPA-AUC value >45 mg·h/L0.650.46 to 0.890.01
  • RR, rate ratio; 95% CI, 95% confidence interval; INS, idiopathic nephrotic syndrome; MMF, mycophenolate mofetil; MPA-AUC, area under the concentration curve of mycophenolic acid.