Table 3.

Comparison of maximum biomarker levels in infants with and without AKI

BiomarkerFold Difference for AKI versus No AKIMedian Values (IQR) in AKI Group (n=27) Median Values (IQR) in Group Without AKI (n=84) P Value
Albumin3.84×107 (2.72×107, 8.63×107)3.13×107 (2.09×107, 5.41×107)0.06
B2M13.4×106 (9.44×106, 19.3×106)12.1×106 (8.20×106, 15.6×106)0.37
Cystatin C2.0× higher18.9×105 (4.38×105, 34.2×105)9.13×105 (2.76×105, 18.4×105)0.01
EGFa4.68×102 (3.63×102, 8.72×102)7.9×102 (4.96×102, 12.0×102)0.05
NGAL1.8× higher6.23×105 (3.43×105, 16.7×105)3.49×105 (2.04×105, 8.77×105)0.04
OPN1.7× higher10.4×105 (5.05×105, 20.8×105)6.14×105 (4.11×105, 10.0×105)0.02
UMODa1.6× lower5.20×105 (2.86×105, 7.28×105)8.33×105 (5.62×105, 11.8×105)0.001
Clusterin1.7× higher4.25×105 (2.15×105, 5.20×105)2.45×105 (1.63×105, 3.90×105)0.05
KIM-14.46×103 (2.21×103, 6.93×103)3.45×103 (1.97×103, 6.77×103)0.75
Osteoactivin1.99×103 (1.19×103, 2.45×103)2.09×103 (1.45×103, 2.82×103)0.31
TFF314.9×103 (6.22×103, 21.3×103)12.2×103 (7.10×103, 22.3×103)0.83
VEGF14.5×102 (11.1×102, 21.0×102)13.5×102 (9.8×102, 24.0×102)0.43
Calbindin8.67×103 (5.70×103, 20.1×103)8.73×103 (6.30×103, 15.9×103)0.79
α-GST3.7× higher91.0×101 (19.1×101, 400×101)24.0×101 (8.49×101, 95.1×101)0.004
  • Unless otherwise noted, values are maximum biomarker levels. Biomarker values are expressed as pg/ml. IQR, interquartile range; B2M, β2-microglobulin; EGF, epithelial growth factor; NGAL, neutrophil gelatinase-associated lipocalin; OPN, osteopontin; UMOD, uromodulin; KIM-1, kidney injury molecule 1; TFF3, trefoil factor 3; VEGF, vascular endothelial growth factor; α-GST, α-glutathione-S-transferase.

  • a Minimum values.