Table 6.

Performance for biomarker value/urine creatinine as potential predictors of AKI

BiomarkerIdeal Crude CutoffCrude AUCaGA-Adjusted AUCa
Albumin3.14×1080.670.67
B2M1.2×1080.670.67
Cystatin C1.1×1070.690.70
NGAL4.8×1060.690.67
OPN5.7×1060.710.69
UMODb6.9×1060.640.68
Clusterin2.4×1060.680.66
VEGF1.2×1040.640.68
α-GST4.5×1030.710.67
  • Unless otherwise noted, values are maximum biomarker levels. Biomarker values are expressed as pg/mg creatinine. AUC, area under the curve; GA, gestational age; β2-microglobulin; NGAL, neutrophil gelatinase-associated lipocalin; OPN, osteopontin; UMOD, uromodulin; VEGF, vascular endothelial growth factor; α-GST, α glutathione-S-transferase.

  • a Log-transformed before analysis to normalize the distribution.

  • b Minimum values.