Table 2.

Association between APOL1 high–risk status and steady decline

ModelAPOL1 Low–Risk GroupAPOL1 High–Risk Group
N485137
Steady decline, %20.040.0
Unadjusted, OR (95% CI)1.002.45 (1.62 to 3.69)
Model 1, OR (95% CI)1.001.70 (1.08 to 2.68)
Model 2, OR (95% CI)1.001.59 (1.00 to 2.52)
Model 2 by subgroups, OR (95% CI)
 eGFR<45 ml/min per 1.73 m21.002.12 (1.00 to 4.50)
 eGFR≥45 ml/min per 1.73 m21.001.46 (0.76 to 2.78)
 UPCR<220 mg/g1.001.40 (0.75 to 2.62)
 UPCR≥220mg/g1.001.68 (0.80 to 3.53)
  • Model 2 P for interaction between APOL1 risk status and eGFR stratified at 45 ml/min per 1.73 m2: 0.42. Model 2 P for interaction between APOL1 risk status and UPCR stratified at 0.22 g/g: 0.55. Model 1 covariates included age at randomization, sex, randomized drug treatment group, randomized BP target, baseline eGFR, log(proteinuria), and diastolic BP. Model 2 added follow-up time for trajectory estimate. OR, odds ratio; 95% CI, 95% confidence interval; UPCR, urine protein-to-creatinine ratio.