Table 3.

Rates of incident stroke, coronary heart disease, and cardiovascular mortality (per 1000 person-years) by diabetes and CKD status in the Jackson Heart Study

OutcomeNEventsUnadjusted Incidence Rate (95% Confidence Interval)Risk Difference Per 1000 person-yr (95% Confidence Interval)
Model 1Model 2
Incident stroke
 No diabetes or CKD2235261.7 (1.1 to 2.4)ReferenceReference
 Diabetes but no CKD431175.7 (2.1 to 9.8)2.8 (0.5 to 5.1); P=0.022.6 (0.5 to 4.7); P=0.02
 CKD but no diabetes23895.9 (2.1 to 9.8)2.9 (−0.1 to 6.1); P=0.082.5 (−0.1 to 5.2); P=0.06
 Diabetes and CKD1841917.0 (9.4 to 24.7)14.8 (6.0 to 23.7); P=0.00113.8 (5.3 to 22.3); P=0.001
Incident coronary heart disease
 No diabetes or CKD2186392.7 (1.8 to 3.5)ReferenceReference
 Diabetes but no CKD409176.1 (3.2 to 9.0)2.4 (−0.1 to 5.0); P=0.072.6 (0.3 to 4.8); P=0.03
 CKD but no diabetes21596.4 (2.2 to 10.7)2.4 (−1.2 to 5.9); P=0.202.4 (−0.8 to 5.5); P=0.15
 Diabetes and CKD1621615.7 (8.0 to 23.3)12.4 (4.4 to 20.3); P=0.00212.8 (4.9 to 20.8); P=0.002
Cardiovascular mortality
 No diabetes or CKD2297302.0 (1.3 to 2.7)ReferenceReference
 Diabetes but no CKD456165.1 (2.6 to 7.5)2.4 (0.4 to 4.4); P=0.022.4 (0.4 to 4.3); P=0.02
 CKD but no diabetes2572213.6 (7.9 to 19.3)7.7 (3.0 to 12.4); P=0.0017.3 (3.0 to 11.5); P=0.001
 Diabetes and CKD2013023.5 (15.1 to 31.9)14.8 (6.8 to 22.8); P<0.00114.8 (7.2 to 22.3); P<0.001
  • Incidence rates were calculated using Poisson regression. Absolute risk differences were estimated by comparing the incidence rates in each group with those in the reference group (participants with no diabetes or CKD) using Poisson regression and adjusted for age, age2, sex, and income (model 1) or additionally adjusted for hypertension, hyperlipidemia, current smoking, and prevalent cardiovascular disease (model 2). Participants with a prior stroke were excluded from the analyses where the outcome was incident stroke. Participants with prior coronary heart disease were excluded from the analyses where the outcome was incident coronary heart disease. However, participants with prior cardiovascular disease (stroke or coronary heart disease) were included in the analyses where the outcome was cardiovascular mortality.