Table 4.

Relative hazards of incident stroke, coronary heart disease, and cardiovascular mortality by diabetes and CKD status in the Jackson Heart Study

OutcomeNEventsUnadjusted HR (95% CI)Model 1 HR (95% CI)Model 2 HR (95% CI)
Incident stroke
 No diabetes or CKD2235261.00 (reference)1.00 (reference)1.00 (reference)
 Diabetes but no CKD431173.23 (1.75 to 5.97)1.94 (0.96 to 3.93)1.83 (0.90 to 3.74)
 CKD but no diabetes23893.65 (1.70 to 7.82)2.43 (1.02 to 5.74)1.91 (0.80 to 4.55)
 Diabetes and CKD1841910.33 (5.70 to 18.73)7.41 (3.87 to 14.18)6.23 (3.22 to 12.09)
Incident coronary heart disease
 No diabetes or CKD2186391.00 (reference)1.00 (reference)1.00 (reference)
 Diabetes but no CKD409172.23 (1.26 to 3.95)1.59 (0.84 to 3.03)1.36 (0.74 to 2.60)
 CKD but no diabetes21592.44 (1.18 to 5.05)1.65 (0.73 to 3.75)1.32 (0.58 to 3.00)
 Diabetes and CKD162165.90 (3.30 to 10.56)4.32 (2.33 to 8.04)3.33 (1.79 to 6.20)
Cardiovascular mortality
 No diabetes or CKD2297301.00 (reference)1.00 (reference)1.00 (reference)
 Diabetes but no CKD456162.52 (1.37 to 4.62)2.06 (1.03 to 4.20)1.90 (0.94 to 3.84)
 CKD but no diabetes257227.00 (4.04 to 12.13)5.04 (2.70 to 9.40)4.22 (2.24 to 7.97)
 Diabetes and CKD2013013.38 (7.45 to 20.56)7.46 (4.15 to 13.43)6.44 (3.53 to 11.78)
  • Relative hazard for each outcome was estimated using the Cox regression and adjusted for age, age2, sex, and income (model 1) or further adjusted for hypertension, dyslipidemia, current smoking, and prevalent cardiovascular disease (model 2). Prevalent cardiovascular disease for each outcome was defined as in Table 3. HR, hazard ratio; 95% CI, 95% confidence interval.