Table 5.

Cardiovascular disease–related mortality

VariablesHazard Ratio (95% CI)P Value
Age, >58 versus ≤58 yr1.23 (0.75 to 2.05)0.41
Sex, men versus women0.97 (0.58 to 1.63)0.92
CVD, present versus absent2.53 (1.43 to 4.46)0.001
Diabetes mellitus, present versus absent2.14 (1.27 to 3.60)0.004
Smoking, yes versus no1.14 (0.65 to 2.01)0.65
SGA, malnourished versus well nourished2.39 (1.42 to 4.03)0.001
eGFR, ≤6.9 versus >6.9 ml/min per 1.73 m22.42 (1.44 to 4.07)<0.001
Calendar year period, 2010–2014 versus 2006–20092.63 (0.73 to 9.48)0.14
Calendar year period, 2010–2014 versus 2000–20051.91 (0.54 to 6.75)0.32
Calendar year period, 2010–2014 versus 1994–19992.34 (0.62 to 8.86)0.21
WBC, >8.0×103 versus ≤8.0×103/μl2.53 (1.50 to 4.27)<0.001
IL-6, >6.7 versus ≤6.7 pg/ml1.43 (0.83 to 2.48)0.20
Troponin T, >0.06 versus ≤0.06 μg/L1.28 (0.76 to 2.16)0.36
hsCRP, >6.4 versus ≤6.4 mg/L1.33 (0.73 to 2.44)0.35
PLT, >261×103 versus ≤261×103/μl1.08 (0.64 to 1.83)0.76
sVCAM-1, >1356 versus ≤1356 ng/ml1.09 (0.63 to 1.89)0.75
sICAM-1, >249 versus ≤249 ng/ml1.10 (0.69 to 1.74)0.70
Albumin, >3.3 versus ≤3.3 g/dl0.98 (0.60 to 1.59)0.92
Ferritin, >122 versus ≤122 ng/ml1.30 (0.81 to 2.07)0.27
IGF-1, >155 versus ≤155 μg/ml1.03 (0.61 to 1.74)0.92
TNF, >12.1 versus ≤12.1 pg/ml0.52 (0.30 to 0.92)0.02
Orosomucoid, >1.1 versus ≤1.1 g/L0.65 (0.38 to 1.11)0.12
  • The output from an imputed multivariate generalized linear model (GENMOD) of hazard ratios (95% CIs) for CVD-related mortality (81 deaths) (Supplemental Table 2) estimated during 60 months of follow-up calculated for each evaluated biomarker and adjusted for other variables. Patient outcomes were censored for renal transplantation. 95% CI, 95% confidence interval; CVD, cardiovascular disease; SGA, subjective global assessment of nutritional status; WBC, white blood cell; hsCRP, high–sensitivity C–reactive protein; PLT, platelet count; sVCAM-1, soluble vascular cellular adhesion molecule 1; sICAM-1, soluble intracellular adhesion molecule.