Table 3.

Incidence rates and hazard ratios for serious fall injuries associated with eGFR and separately, urinary albumin-to-creatinine ratio

eGFR and ACR LevelsIncidencea (95% CI)Hazard Ratio (95% CI)
Model 1Model 2Model 3Model 4
eGFR, ml/min per 1.73 m2
 ≥6021.7 (20.3 to 23.2)1 (reference)1 (reference)1 (reference)1 (reference)
 45–5926.6 (22.6 to 31.3)1.03 (0.86 to 1.23)0.98 (0.81 to 1.17)0.94 (0.79 to 1.13)0.91 (0.76 to 1.09)
 <4538.3 (31.2 to 47.0)1.38 (1.10 to 1.72)1.23 (0.99 to 1.55)1.12 (0.89 to 1.40)1.09 (0.86 to 1.37)
ACR, mg/g
 <3021.3 (20.0 to 22.8)1 (reference)1 (reference)1 (reference)1 (reference)
 30–29931.7 (27.5 to 36.5)1.48 (1.26 to 1.73)1.33 (1.13 to 1.56)1.33 (1.13 to 1.55)1.31 (1.11 to 1.54)
 ≥30042.2 (31.3 to 56.9)2.32 (1.70 to 3.15)1.90 (1.39 to 2.62)1.86 (1.34 to 2.57)1.81 (1.30 to 2.50)
  • Model 1 is adjusted for age, race, sex, and geographic region of residence. Model 2 is adjusted for variables in model 1 and education, income, smoking status, coronary heart disease, diabetes mellitus, stroke, atrial fibrillation, body mass index, C-reactive protein >3 mg/L, hypotension, and use of antihypertensive medication. Model 3 is adjusted for variables in model 2 and albumin-to-creatinine ratio (ACR) for the model of eGFR and eGFR for the model of ACR. Model 4 is adjusted for variables in model 3 and cognitive impairment, depressive symptoms, exhaustion, impaired mobility, self-reported falls in the year before baseline, use of psychoactive medication, and polypharmacy. 95% CI, 95% confidence interval; ACR, albumin-to-creatinine ratio.

  • a Incidence per 1000 person-years.