Table 3.

Presence of baseline clinical overt cardiovascular disease

VariableRelative Risk Ratio (95% CI)P Value
Age, >58 versus ≤58 yr1.31 (1.22 to 1.41)<0.001
Sex, men versus women1.06 (0.99 to 1.15)0.11
Diabetes mellitus, present versus absent1.24 (1.14 to 1.34)<0.001
Smoking, yes versus no1.15 (1.07 to 1.23)<0.001
SGA, malnourished versus well nourished1.10 (1.02 to 1.19)0.02
eGFR, ≤7.0 versus >7.0 ml/min per 1.73 m20.97 (0.91 to 1.04)0.46
IL-6, >7.0 versus ≤7.0 pg/ml1.10 (1.02 to 1.19)0.01
sVCAM-1, >1355 versus ≤1355 ng/ml1.09 (1.01 to 1.17)0.04
Orosomucoid, >1.1 versus ≤1.1 g/L1.08 (0.99 to 1.17)0.08
Troponin T, >0.05 versus ≤0.05 μg/L1.06 (0.98 to 1.15)0.13
WBC, >7.7×103 versus ≤7.7×103/μl1.05 (0.97 to 1.13)0.25
hsCRP, >5.3 versus ≤5.3 mg/L1.02 (0.93 to 1.11)0.71
PLT, >253×103 versus ≤253×103/μl1.01 (0.94 to 1.08)0.87
TNF, >12.2 versus ≤12.2 pg/ml0.97 (0.91 to 1.05)0.48
sICAM-1, >249 versus ≤249 ng/ml0.97 (0.91 to 1.04)0.43
Ferritin, >127 versus ≤127 ng/ml0.96 (0.90 to 1.03)0.30
IGF-1, >163 versus ≤163 μg/ml0.93 (0.86 to 1.00)0.05
Albumin, >3.3 versus ≤3.3 g/dl0.89 (0.83 to 0.95)0.001
  • The output from an imputed multivariate generalized linear model (GENMOD) of classifiers of baseline clinical cardiovascular disease incorporating multiple factors associated with cardiovascular disease in univariate analysis plus each of the studied biomarkers. Results are presented as relative risk ratios with 95% CIs. 95% CI, 95% confidence interval; SGA, subjective global assessment of nutritional status; sVCAM-1, soluble vascular cellular adhesion molecule 1; WBC, white blood cell; hsCRP, high–sensitivity C–reactive protein; PLT, platelet count; sICAM-1, soluble intracellular adhesion molecule.