Table 3.

Strongest genetic associations in patients with nondiabetic ESRD (additive, fully adjusted model)

GeneSNPMinor AlleleN Patients/ControlsMAF Patients/ControlsP ValueOR95% CI
LRP2rs11898106G868/7130.30/0.260.041.211.01 to 1.46
LRP2rs78750385G885/7200.11/0.090.031.341.03 to 0.76
CUBNrs3808925C873/7150.17/0.150.021.301.05 to 1.62
CUBNrs2796838T883/7180.40/0.430.050.850.72 to 1.00
CUBNrs11254267A882/7170.092/0.070.021.431.06 to 1.93
CUBNrs7921129T876/7140.32/0.350.050.840.71 to 1.00
  • SNP, single-nucleotide polymorphism; MAF, minor allele frequency; OR, odds ratio; 95% CI, 95% confidence interval; LRP2, megalin; CUBN, cubilin.