Table 2.

Correlation between albumin-to-creatinine ratio, protein-to-creatinine ratio, and 24-hour urinary protein excretion with severity of IgA nephropathy

CharacteristicsACRProtein-to-Creatinine Ratio24-h UPE
Level, mg/gP ValueLevel, g/gP ValueLevel, g/dP Value
CKD stagea<0.001<0.001<0.001
 1321.5 (164.2, 544.9)0.50 (0.21, 0.99)1.18 (0.67, 2.33)
 2472.2 (261.8, 730.2)0.71 (0.31, 1.59)1.44 (0.93, 2.91)
 3703.1 (380.6, 1031.2)1.11 (0.57, 2.15)2.20 (1.44, 3.60)
 41218.4 (894.1, 1864.7)3.44 (1.43, 6.28)4.60 (3.03, 6.66)
Hypertension<0.001<0.001<0.001
 Without398.5 (186.5, 668.8)0.56 (0.22, 1.17)1.38 (0.77, 2.60)
 With612.5 (373.7, 955.2)1.08 (0.56, 2.16)2.37 (1.22, 4.06)
Oxford classification
 M lesion0.130.650.16
  0415.3 (179.2, 693.9)0.64 (0.22, 1.59)1.30 (0.74, 3.08)
  1470.6 (246.8, 767.2)0.71 (0.31, 1.60)1.69 (0.94, 3.14)
 E lesion0.940.870.74
  0468.0 (226.5, 740.0)0.71 (0.30, 1.53)1.48 (0.88, 3.18)
  1455.6 (243.7, 759.5)0.70 (0.29, 1.71)1.71 (0.84, 3.11)
 S lesion0.030.670.92
  0370.7 (163.9, 768.4)0.69 (0.21, 1.81)1.53 (0.78, 3.72)
  1484.3 (269.2, 744.4)0.71 (0.33, 1.50)1.67 (0.91, 3.02)
 T lesion<0.001<0.001<0.001
  0379.3 (176.8, 616.4)0.56 (0.22, 1.20)1.30 (0.74, 2.64)
  1528.0 (334.0, 846.4)0.82 (0.41, 1.67)1.93 (1.11, 3.50)
  2777.9 (592.7, 1277.6)1.64 (0.76, 2.89)2.89 (1.52, 4.70)
 Extracapillary  proliferation
  0408.5 (192.2, 709.9)0.020.63 (0.23, 1.43)0.131.44 (0.76, 3.06)0.17
  1503.3 (264.4, 803.9)0.75 (0.35, 1.71)1.72 (0.97, 3.21)
  • Values are shown in median (interquartile range). ACR, albumin-to-creatinine ratio; UPE, urinary protein excretion; M lesion, mesangial hypercellularity score; E lesion, presence of endocapillary proliferation; S lesion, segmental glomerulosclerosis/adhesion; T lesion, severity of tubular atrophy/interstitial fibrosis.

  • a CKD stages 1–4 were divided by eGFR≥90, =60–89, =30–59, and =15–29 ml/min per 1.73 m2, respectively, according to the Kidney Disease Outcomes Quality Initiative.