Table 3.

Multivariable linear regression model of the annual decline in eGFR stratified by baseline eGFR

Baseline FactoreGFR (CKD-EPI)<60 ml/min per 1.73 m2 (n=78)eGFR (CKD-EPI) 60–89 ml/min per 1.73 m2 (n=118)eGFR (CKD-EPI)≥90 ml/min per 1.73 m2 (n=324)
β Coefficient (95% CI)P Valueβ Coefficient (95% CI)P Valueβ Coefficient (95% CI)P Value
Age (per 5 yr)0.65 (0.09–1.22)0.02−0.25 (−0.79 to 0.29)0.36−0.38 (−0.70 to −0.09)0.01
Female−1.81 (−4.44 to 0.81)0.170.83 (−2.01 to 3.67)0.561.76 (0.51– to 3.01)0.01
Baseline CKD-EPI (per 5–ml/min per 1.73 m2 increase)−0.11 (−0.18 to −0.05)0.001
Diabetes−2.49 (−5.27 to 0.30)0.08
Urine ACR (log mg/g)−0.92 (−1.65 to −0.20)0.01−1.03 (−1.71 to −0.35)0.003−0.41 (−0.76 to −0.06)0.02
Model R2, %23.58.87.6
• Final model (n=520). A final multivariable model was identified using covariates selected for entry into a linear regression model. All the variables described in Table 2 were included in the selection. The following covariates were entered into the final model: eGFR<60 ml/min per 1.73 m2: sex, age, urine albumin-to-creatinine ratio (ACR), diabetes; eGFR 60–89 ml/min per 1.73 m2: sex, age, urine ACR; eGFR≥90 ml/min per 1.73 m2: sex, age, urine ACR, baseline eGFR (calculated with CKD-Epidemiology Collaboration formula). CKD-EPI, CKD-Epidemiology Collaboration; 95% CI, 95% confidence interval; ACR, albumin-to-creatinine ratio.