Table 2.

Patient demographics and baseline characteristics (safety population)

CharacteristicCohortAll Patients, n=145
A, n=24B, n=24C, n=24D, n=24E, n=24F, n=25
Age, yr, mean (min, max)65.9 (44, 83)64.3 (32, 79)59.2 (25, 78)69.8 (48, 81)61.8 (32, 78)65.2 (41, 77)64.4 (25, 83)
Men, n (%)5 (20.8)7 (29.2)8 (33.3)13 (54.2)8 (33.3)12 (48.0)53 (36.6)
Weight, kg, mean (min, max)89.9 (53, 139)84.5 (55, 122)89.5 (48, 138)85.1 (48, 125)88.3 (56, 140)84.7 (48, 122)87.0 (48, 140)
Race, n (%)
 White17 (70.8)14 (58.3)14 (58.3)17 (70.8)14 (58.3)17 (68.0)93 (64.1)
 Black7 (29.2)7 (29.2)9 (37.5)5 (20.8)7 (29.2)7 (28.0)42 (29.0)
 Other03 (12.5)1 (4.2)2 (8.3)3 (12.5)1 (4.0)10 (6.9)
Prevalence, n (%)
 Diabetes16 (66.7)17 (70.8)18 (75.0)15 (62.5)13 (54.2)12 (48.0)91 (62.8)
 Hypertension10 (41.7)13 (54.2)14 (58.3)11 (45.8)15 (62.5)16 (64.0)79 (54.5)
Hb, g/dl, mean (min, max)9.6 (7.4,10.6)9.7 (8.1, 10.5)9.8 (8.8, 10.6)9.7 (7.0, 10.6)9.9 (8.6, 10.7)9.7 (8.6, 10.5)9.7 (7.0, 10.7)
Ferritin, ng/ml, mean (min, max)322 (49, 1711)282 (42, 744)261 (33, 877)283 (38, 1289)207 (32, 803)306 (37, 689)277 (32, 1711)
 >100, n (%)23 (95.8)19 (79.2)18 (75.0)17 (70.8)15 (62.5)20 (80.0)112 (77.2)
 ≤100, n (%)1 (4.2)5 (20.8)6 (25.0)7 (29.2)9 (37.5)5 (20.0)33 (22.8)
TSAT, %, mean (min, max)24.5 (9, 48)19.9 (6, 41)21.0 (12, 37)24.4 (9, 41)20.9 (12, 36)21.5 (11, 39)22.0 (6, 48)
 >20, n (%)18 (75.0)12 (50.0)12 (50.0)17 (70.8)12 (50.0)15 (60.0)86 (59.3)
 ≤20, n (%)6 (25.0)12 (50.0)12 (50.0)7 (29.2)12 (50.0)10 (40.0)59 (40.7)
Iron replete,a n (%)18 (75.0)11 (45.8)11 (45.8)14 (58.3)9 (37.5)13 (52.0)76 (52.4)
  • min, max, minimum, maximum; Hb, hemoglobin; TSAT, transferrin saturation.

  • a Iron replete is defined as TSAT>20% and ferritin >100 ng/ml.