Table 2.

Rate of change in total kidney volume by CKD stage

VariableCKD Stage 1 (n=425)CKD Stage 2 (n=616)CKD Stage 3 (n=231)
Tolvaptan (n=267)Placebo (n=158)Tolvaptan (n=402)Placebo (n=214)Tolvaptan (n=147)Placebo (n=84)
Rate of TKV growth, %/yr3.1±5.25.1±4.62.1±5.05.3±5.04.2±7.57.2±7.0
Treatment effect (95% CI), %/yr−1.99 (−2.85 to −1.13)−3.12 (−3.93 to −2.31)−2.61 (−4.08 to −1.17)
P value<0.001<0.001<0.001
Relative treatment effect, %40.460.439.8
  • Values expressed with a plus/minus sign are the mean±SD. TKV, total kidney volume; 95% CI, 95% confidence interval.