Table 1.

Proposed criteria for diagnosis of lupus podocytopathy

ParameterFeatures
ClinicalDiagnosis of SLE by ACR criteria; full nephrotic syndrome (i.e., nephrotic-range proteinuria, hypoalbuminemia, and edema)
Light microscopyNormal glomeruli or FSGS; mesangial proliferation permitted; endocapillary proliferation, necrosis, and/or crescents not permitted
Immunofluorescence microscopyDeposits absent or confined to mesangium
Electron microscopyDiffuse and severe foot process effacement (typically >70%); deposits absent or confined to mesangium
  • ACR, American College of Rheumatology.