Table 3.

Treatment effect on the primary composite cardiovascular end point: prespecified sensitivity analyses

Type of AnalysisRelative Hazard (95% Confidence Interval)P Value
Unadjusted ITT analysis0.93 (0.85 to 1.02)0.11
Multivariable-adjusted ITT analysis0.88 (0.79 to 0.97)0.01
Inverse probability of censoring weights0.81 (0.70 to 0.92)0.03
Censor at PTX0.90 (0.82 to 0.99)0.03
Censor at KT0.90 (0.82 to 0.99)0.03
Censor at commercial cinacalcet use0.90 (0.82 to 0.99)<0.001
Censor at PTX, commercial cinacalcet, or KT0.84 (0.76 to 0.93)<0.001
Age <65 yr0.99 (0.88 to 1.11)Interaction: 0.01
Age ≥65 yr0.74 (0.63 to 0.86)
  • Data obtained from references 1 and 20. ITT, intention-to-treat; PTX, parathyroidectomy; KT, kidney transplant.