Table 3.

Factors associated with ESRD by immunosuppression status

VariablesHazard Ratio95% Confidence Interval
Unadjusted
 Immunosuppression
  None1
  CNIs with or without glucocorticoids or glucocorticoids alone0.500.29 to 0.87
Adjusteda
 Immunosuppression
  None1
  CNIs with or without glucocorticoids or glucocorticoids alone0.490.28 to 0.86
 Age per 1-yr increase1.000.99 to 1.01
 Men1.150.76 to 1.73
 FSGS variant
  NOS1
  Tip0.210.09 to 0.48
  Collapsing1.710.99 to 2.95
 Baseline eGFR <30 ml/min per 1.73 m24.282.81 to 6.48
 Baseline proteinuria ≥3.5 g/d1.250.68 to 2.29
 Serum albumin at biopsy per 1 g/dl higher0.690.53 to 0.90
 Hypertension at baseline1.330.81 to 2.20
Adjusted (adults only)b
 Immunosuppression
  None1
  CNIs with or without glucocorticoids or glucocorticoids alone0.430.21 to 0.86
  • CNI, calcineurin inhibitor; NOS, not otherwise specified.

  • a Cox regression adjusted for immunosuppression, age, sex, black race, FSGS variant, and baseline eGFR, proteinuria, serum albumin, and hypertension.

  • b Cox regression in adult patients only adjusted for immunosuppression, age, sex, black race, FSGS variant, and baseline eGFR, proteinuria, serum albumin, and hypertension.