Table 1.

Baseline characteristics of all patients and four groups stratified by eGFR and BUN at discharge

VariablesTotaleGFR≥45 ml/min per 1.73 m2eGFR<45 ml/min per 1.73 m2P Value
BUN<25 mg/dl (Group 1)BUN≥25 mg/dl (Group 2)BUN<25 mg/dl (Group 3)BUN≥25 mg/dl (Group 4)
No. of patients444919814185691481
Age, yr72.6±13.868.4±14.873.0±13.374.9±12.477.1±11.0<0.001
Sex, % men58.361.567.248.255.2<0.001
Etiology, %
 Ischemic30.625.324.938.136.5<0.001
 Hypertensive18.017.415.319.019.30.20
 Valvular18.917.323.217.220.50.01
 Idiopathic dilated13.216.214.89.510.1<0.001
Medical history, %
 Prior hospitalization for heart failure35.326.036.634.147.7<0.001
 Hypertension69.564.362.776.176.0<0.001
 Dyslipidemia37.335.030.143.340.4<0.001
 Diabetes33.730.828.936.438.0<0.001
 Chronic obstructive pulmonary disease11.811.116.510.212.00.01
 Stroke13.611.814.412.716.10.01
Atrial fibrillation at discharge, %31.129.639.030.431.3<0.001
Reduced ejection fraction (≤40%), %53.455.258.949.950.70.003
Medications at discharge, %
 Loop diuretic82.677.290.278.989.1<0.001
 Spironolactone or eplerenone49.053.960.346.640.2<0.001
 Angiotensin–converting enzyme inhibitor31.234.037.832.325.3<0.001
 Angiotensin II receptor blocker46.644.343.347.650.20.003
β-Blocker68.167.967.073.166.70.04
Body mass index, kg/m221.6±4.221.9±4.420.4±4.322.0±4.421.3±3.8<0.001
Systolic BP at discharge, mmHg114.8±17.6113.4±16.7110.1±15.8118.3±17.6116.6±18.8<0.001
Diastolic BP at discharge, mmHg63.9±14.164.4±11.362.1±11.165.9±11.863.1±18.2<0.001
Heart rate at discharge, beats per minute70.2±11.970.9±12.071.2±11.670.4±11.869.0±11.7<0.001
BUN at discharge, mg/dl27.1±16.416.6±4.231.4±14.619.6±4.142.8±17.2<0.001
Serum creatinine at discharge, mg/dl1.35±1.200.83±0.210.95±0.191.67±2.042.03±1.33<0.001
eGFR at discharge, ml/min per 1.73 m249.2±23.267.5±18.256.9±12.935.3±8.727.8±10.0<0.001
Serum sodium at discharge, mEq/L138.4±4.0138.9±3.7137.4±3.9139.0±3.6137.8±4.4<0.001
Hemoglobin at discharge, g/dl12.0±2.312.8±2.212.5±2.311.5±2.011.1±2.1<0.001
NYHA functional class at discharge, %
 I94.396.091.495.792.4<0.001
 II5.74.08.64.37.6<0.001
  • Values are the means±SDs, proportions (percentages), or medians (interquartile ranges). NYHA, New York Heart Association.