Table 4.

Factors univariately associated with incident ESRD among patients with primary hyperoxaluria without ESRD at diagnosis

VariableHazard Ratio (95% CI)P Value
PH113.17 (3.19 to 54.38)<0.001
Male1.39 (0.82 to 2.37)0.22
Age at symptoms1.00 (0.97 to 1.03)0.98
Age at diagnosis1.02 (1.00 to 1.04)0.02
U[vol] , ml/1.73m2 per 24h1.00 (1.00 to 1.00)0.31
U[ox] , mmol/1.73m2 per 24h1.13 (0.94 to 1.37)0.20
U[ox] , mmol/1.73m2 per 24h (Q4)3.40 (1.40 to 7.90)0.01
U[Citrate] , mg/1.73m2 per 24h1.00 (1.00 to 1.00)0.24
U[Ca] , mg/1.73m2 per 24h1.00 (0.99 to 1.00)0.29
U[Phos] , mg/1.73m2 per 24h1.00 (1.00 to 1.00)0.59
eGFR, ml/min per 1.73m20.96 (0.94 to 0.99)0.002
  • PH1, primary hyperoxaluria type 1; U[vol], urinary volume; U[ox], urinary oxalate; Q4, quintile 4; U[Citrate], urinary citrate; U[Ca], urinary calcium; U[Phos], urinary phosphate; 95% CI, 95% confidence interval.