Table 1.

Clinical characteristics of patients with primary hyperoxaluria who had or did not have ESRD at or before diagnosis

CharacteristicsWithout ESRD (n=297)With ESRD (n=112)P Value
Type of PH, % (n)<0.001
 PH164.6 (192)93.8 (105)
 PH211.8 (35)3.6 (4)
 PH312.8 (38)0 (0)
 Unclassified10.8 (32)2.7 (3)
Sex, % (n)0.05
 Female42.8 (127)53.6 (60)
 Male57.2 (170)46.4 (52)
Median age, y
 At diagnosis8.1 (4.0, 18.2)25.3 (6.8, 42.0)<0.001
 At symptom onset4.5 (1.7, 11.3)9.4 (2.0, 21.6)0.02
Median time between initial symptoms and diagnosis, y1.4 (0.1, 7.5)3.5 (0.3, 21.0)<0.001
Median eGFR, ml/min per 1.73 m273.0 (56.4, 97.5)6.6 (3.9, 13.8)<0.001
  • Median values are expressed with 25th, 75th percentiles. PH, primary hyperoxaluria; PH1, primary hyperoxaluria type 1; PH2, primary hyperoxaluria type 2; PH3, primary hyperoxaluria type 3.