Table 4.

Histologic and immunohistochemical findings and serum levels of complement fractions in the 30 patients who underwent renal biopsy divided into low and normal serum C3 groups

sC3 Level per Patient IDBerden ClassificationTrombothicMicroangiopathyGlomerular C3cGlomerular C4dGlomerular C5b-9sC5b-9 (ng/ml)Glomerular BbsBb
Low sC3
 1CrescenticYes++++++NegativeNANegativeNA
 2CrescenticNo+NANANANANA
 10MixedNo+++NegativeNegative946Negative0.8
 17CrescenticYes; hemolysis+++++1065Negative1.19
 19ScleroticYes++++++++1255+0.6
 20CrescenticNo+++++++NANegativeNA
 22MixedNo++++++++870Negative0.64
 26CrescenticYes+++++NANegativeNA
 28ScleroticNo++++++Negative900Negative0.58
 30MixedYes; hemolysis++++NegativeNANegativeNA
Normal sC3
 3CrescenticNo++Negative+NANegativeNA
 4CrescenticYes++NANANANANA
 5CrescenticNoNegativeNegative+1313Negative1.41
 6CrescenticNoNANANANANANA
 7MixedNo++NegativeNegative7000Negative3.51
 8CrescenticYes++++++1012Negative1.42
 9ScleroticNo+++++++2052Negative0.81
 11CrescenticNo++NANANANANA
 12CrescenticNoNegativeNegativeNegative1981Negative1.1
 13CrescenticNo++NegativeNegativeNANegativeNA
 14CrescenticNo++++++2197+0.9
 15CrescenticNo+++++4632Negative1.72
 16FocalNo+++++1664Negative0.8
 18CrescenticNo++++++++NA+NA
 21CrescenticNo+++++NegativeNANegativeNA
 23MixedYes+++++1105Negative0.81
 24FocalNo; hemolysis++++Negative1092Negative1.12
 25CrescenticNo+++++2066Negative0.84
 27FocalNoNANegativeNegativeNANegativeNA
 29CrescenticNoNANANANANANA
  • Negative indicates diffuse negative, focal slightly positive; + indicates diffuse slightly positive, focal moderately positive; ++ indicates diffuse moderately positive, focal intensely positive; +++ indicates diffuse intensely positive. sC3, serum C3; ID, identification; sC5b-9, serum C5b-9; sBb, serum Bb; NA, not available.