Table 1.

Main demographic and clinical characteristics of the patients with renal ANCA-associated vasculitis

CharacteristicValue (n=46)
Men/women (n/n)29/17
Age at disease onset- years (yr)64.7±15
Type of AAV (GPA/MPA) (n/n)17/29
ANCA specificity (PR3-ANCA/MPO-ANCA) (n/n)17/29
BVAS 18.2±6.5
Organ involvement (n)
 Renal-limited vasculitis12
 Pulmonary involvement29
 Peripheral nervous system13
 Other19
Mean arterial pressure (mmHg)100.5±7.8
eGFR (ml/min per 1.73 m2)11.3 (2.4–45.0)
Hemoglobin (g/dl)9.5±1.7
Platelet count (cells/mm3)219 (44–691)
LDH (IU/L)405.3±146.9
sC3 (mg/dl)110 (47–211)
sC4 (mg/dl)31 (8.3–85.2)
Haptoglobin (mg/dl)289 (13.8–774)
C-reactive protein (mg/L)64.3 (0.7–226)
Proteinuria (g/24 h)3 (0.3–7.6)
Immunosuppressive therapy (n)
 Cyclophosphamide + prednisone31
 Cyclophosphamide + prednisone + plasma exchange4
 Methotrexate + prednisone2
 NA9
  • Values are expressed as numbers of patients, median (range), or mean±SD. Mean arterial pressure was calculated as (2×diastolic pressure + systolic pressure)/3. AAV, ANCA-associated vasculitis; GPA, granulomatosis with polyangiitis (Wegener granulomatosis); MPA, microscopic polyangiitis; PR3-ANCA, proteinase-3 ANCA antibodies; MPO-ANCA, myeloperoxidase-ANCA antibodies; BVAS, Birmingham Vasculitis Activity Score; LDH, lactate dehydrogenase; sC3, serum levels of C3; sC4, serum levels of C4; NA, not available.