Table 4.

Odds ratios and 95% confidence intervals for incident ESRD for urinary biomarkers modeled categorically and continuously not indexed to urinary creatinine (n=321)

Unadjusted*Adjusted for AgeAdjusted for Age and eGFRAdjusted for Age, eGFR, and lnUACR
OR (95% CI)P ValueOR (95% CI)P ValueOR (95% CI)P ValueOR (95% CI)P Value
L-FABP (ng/ml)
 Undetectable (0)ReferenceReferenceReferenceReference
 >0 to <2.40.75 (0.36 to 1.56)0.430.75 (0.36 to 1.56)0.440.73 (0.35 to 1.54)0.410.78 (0.37 to 1.64)0.51
 ≥2.4 to <7.621.03 (0.50 to 2.09)0.941.03 (0.50 to 2.09)0.940.95 (0.47 to 1.95)0.901.02 (0.49 to 2.09)0.97
 ≥7.622.04 (0.88 to 4.73)0.102.06 (0.89 to 4.77)0.091.77 (0.75 to 4.18)0.191.66 (0.70 to 3.94)0.25
 P trend0.140.140.270.31
KIM-1 (pg/ml)
 ≤354.45ReferenceReferenceReferenceReference
 >354.45 to ≤624.420.98 (0.50 to 1.91)0.960.99 (0.51 to 1.92)0.970.94 (0.48 to 1.84)0.800.94 (0.48 to 1.86)0.86
 >624.42 to ≤1363.161.33 (0.68 to 2.61)0.411.33 (0.68 to 2.60)0.411.33 (0.68 to 2.63)0.411.47 (0.74 to 2.93)0.27
 >1363.161.22 (0.61 to 2.44)0.581.21 (0.60 to 2.43)0.601.12 (0.55 to 2.29)0.751.16 (0.56 to 2.40)0.68
 P trend0.430.450.550.45
 Continuous (log scale; per SD)1.10 (0.85 to 1.41)0.471.09 (0.85 to 1.41)0.481.09 (0.84 to 1.40)0.521.12 (0.86 to 1.45)0.40
NAG (milliunits/ml)
 ≤2.19ReferenceReferenceReferenceReference
 >2.19 to ≤3.961.09 (0.53 to 2.24)0.811.09 (0.53 to 2.24)0.821.10 (0.54 to 2.25)0.801.27 (0.61 to 2.64)0.53
 >3.96 to ≤6.930.75 (0.36 to 1.55)0.430.75 (0.36 to 1.55)0.440.68 (0.32 to 1.90)0.300.76 (0.36 to 1.62)0.48
 >6.930.90 (0.42 to 1.95)0.800.91 (0.42 to 1.95)0.800.88 (0.41 to 1.90)0.740.91 (0.95 to 1.99)0.82
 P trend0.550.560.460.51
 Continuous (log scale; per SD)0.96 (0.74 to 1.24)0.770.96 (0.74 to 1.24)0.770.93 (0.71 to 1.21)0.580.95 (0.73 to 1.23)0.68
NGAL (ng/ml)
 ≤8.1ReferenceReferenceReferenceReference
 >8.1 to ≤18.90.75 (0.37 to 1.51)0.420.75 (0.37 to 1.51)0.420.73 (0.37 to 1.48)0.390.78 (0.38 to 1.57)0.48
 >18.9 to ≤42.20.86 (0.42 to 1.75)0.680.86 (0.42 to 1.75)0.670.83 (0.40 to 1.70)0.610.78 (0.38 to 1.64)0.52
 42.2 ng/ml1.49 (0.66 to 3.38)0.341.48 (0.65 to 3.36)0.351.26 (0.55 to 2.88)0.591.23 (0.53 to 2.85)0.63
 P trend0.410.410.660.77
 Continuous (log scale; per SD)1.16 (0.85 to 1.59)0.341.16 (0.85 to 1.59)0.351.05 (0.76 to 1.46)0.751.03 (0.74 to 1.43)0.86
  • lnUACR, natural log of the urinary albumin-to-creatinine ratio; OR, odds ratio; 95% CI, 95% confidence interval; L-FABP, urinary liver fatty acid binding protein; KIM-1/Cr, urinary kidney injury molecule 1; NAG, urinary N-acetyl-β-d-glucosaminidase; NGAL, urinary neutrophil gelatinase–associated lipocalin.

  • a Matching factors incorporated into conditional logistic regression model with no additional covariates.