Odds ratios and 95% confidence intervals for incident ESRD for urinary biomarkers modeled categorically and continuously not indexed to urinary creatinine (n=321)
| Unadjusted* | Adjusted for Age | Adjusted for Age and eGFR | Adjusted for Age, eGFR, and lnUACR | |||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | |
| L-FABP (ng/ml) | ||||||||
| Undetectable (0) | Reference | Reference | Reference | Reference | ||||
| >0 to <2.4 | 0.75 (0.36 to 1.56) | 0.43 | 0.75 (0.36 to 1.56) | 0.44 | 0.73 (0.35 to 1.54) | 0.41 | 0.78 (0.37 to 1.64) | 0.51 |
| ≥2.4 to <7.62 | 1.03 (0.50 to 2.09) | 0.94 | 1.03 (0.50 to 2.09) | 0.94 | 0.95 (0.47 to 1.95) | 0.90 | 1.02 (0.49 to 2.09) | 0.97 |
| ≥7.62 | 2.04 (0.88 to 4.73) | 0.10 | 2.06 (0.89 to 4.77) | 0.09 | 1.77 (0.75 to 4.18) | 0.19 | 1.66 (0.70 to 3.94) | 0.25 |
| P trend | 0.14 | 0.14 | 0.27 | 0.31 | ||||
| KIM-1 (pg/ml) | ||||||||
| ≤354.45 | Reference | Reference | Reference | Reference | ||||
| >354.45 to ≤624.42 | 0.98 (0.50 to 1.91) | 0.96 | 0.99 (0.51 to 1.92) | 0.97 | 0.94 (0.48 to 1.84) | 0.80 | 0.94 (0.48 to 1.86) | 0.86 |
| >624.42 to ≤1363.16 | 1.33 (0.68 to 2.61) | 0.41 | 1.33 (0.68 to 2.60) | 0.41 | 1.33 (0.68 to 2.63) | 0.41 | 1.47 (0.74 to 2.93) | 0.27 |
| >1363.16 | 1.22 (0.61 to 2.44) | 0.58 | 1.21 (0.60 to 2.43) | 0.60 | 1.12 (0.55 to 2.29) | 0.75 | 1.16 (0.56 to 2.40) | 0.68 |
| P trend | 0.43 | 0.45 | 0.55 | 0.45 | ||||
| Continuous (log scale; per SD) | 1.10 (0.85 to 1.41) | 0.47 | 1.09 (0.85 to 1.41) | 0.48 | 1.09 (0.84 to 1.40) | 0.52 | 1.12 (0.86 to 1.45) | 0.40 |
| NAG (milliunits/ml) | ||||||||
| ≤2.19 | Reference | Reference | Reference | Reference | ||||
| >2.19 to ≤3.96 | 1.09 (0.53 to 2.24) | 0.81 | 1.09 (0.53 to 2.24) | 0.82 | 1.10 (0.54 to 2.25) | 0.80 | 1.27 (0.61 to 2.64) | 0.53 |
| >3.96 to ≤6.93 | 0.75 (0.36 to 1.55) | 0.43 | 0.75 (0.36 to 1.55) | 0.44 | 0.68 (0.32 to 1.90) | 0.30 | 0.76 (0.36 to 1.62) | 0.48 |
| >6.93 | 0.90 (0.42 to 1.95) | 0.80 | 0.91 (0.42 to 1.95) | 0.80 | 0.88 (0.41 to 1.90) | 0.74 | 0.91 (0.95 to 1.99) | 0.82 |
| P trend | 0.55 | 0.56 | 0.46 | 0.51 | ||||
| Continuous (log scale; per SD) | 0.96 (0.74 to 1.24) | 0.77 | 0.96 (0.74 to 1.24) | 0.77 | 0.93 (0.71 to 1.21) | 0.58 | 0.95 (0.73 to 1.23) | 0.68 |
| NGAL (ng/ml) | ||||||||
| ≤8.1 | Reference | Reference | Reference | Reference | ||||
| >8.1 to ≤18.9 | 0.75 (0.37 to 1.51) | 0.42 | 0.75 (0.37 to 1.51) | 0.42 | 0.73 (0.37 to 1.48) | 0.39 | 0.78 (0.38 to 1.57) | 0.48 |
| >18.9 to ≤42.2 | 0.86 (0.42 to 1.75) | 0.68 | 0.86 (0.42 to 1.75) | 0.67 | 0.83 (0.40 to 1.70) | 0.61 | 0.78 (0.38 to 1.64) | 0.52 |
| 42.2 ng/ml | 1.49 (0.66 to 3.38) | 0.34 | 1.48 (0.65 to 3.36) | 0.35 | 1.26 (0.55 to 2.88) | 0.59 | 1.23 (0.53 to 2.85) | 0.63 |
| P trend | 0.41 | 0.41 | 0.66 | 0.77 | ||||
| Continuous (log scale; per SD) | 1.16 (0.85 to 1.59) | 0.34 | 1.16 (0.85 to 1.59) | 0.35 | 1.05 (0.76 to 1.46) | 0.75 | 1.03 (0.74 to 1.43) | 0.86 |
lnUACR, natural log of the urinary albumin-to-creatinine ratio; OR, odds ratio; 95% CI, 95% confidence interval; L-FABP, urinary liver fatty acid binding protein; KIM-1/Cr, urinary kidney injury molecule 1; NAG, urinary N-acetyl-β-d-glucosaminidase; NGAL, urinary neutrophil gelatinase–associated lipocalin.
a Matching factors incorporated into conditional logistic regression model with no additional covariates.