Table 3.

Odds ratios and 95% confidence intervals for incident ESRD for urinary biomarkers modeled categorically and continuously indexed to urinary creatinine (n=321)

UnadjustedaAdjusted for AgeAdjusted for Age and eGFRAdjusted for Age, eGFR, and lnUACR
OR (95% CI)P ValueOR (95% CI)P ValueOR (95% CI)P ValueOR (95% CI)P Value
L-FABP/Cr (ng/mg)
 Undetectable (0 ng/ml)ReferenceReferenceReferenceReference
 Detectable; below LOD0.74 (0.35 to 1.53)0.410.74 (0.35 to 1.54)0.420.72 (0.34 to 1.51)0.380.77 (0.36 to 1.62)0.49
 ≥0.97 to <6.670.99 (0.48 to 2.03)0.970.99 (0.48 to 2.04)0.970.93 (0.45 to 1.92)0.850.99 (0.48 to 2.07)0.99
 ≥6.672.22 (0.92 to 5.33)0.082.23 (0.93 to 5.35)0.071.87 (0.77 to 4.58)0.171.75 (0.71 to 4.30)0.22
 P trend0.150.150.290.32
KIM-1/Cr (pg/mg)
 Q1≤432.30ReferenceReferenceReferenceReference
 Q2>432.30 to ≤789.691.25 (0.63 to 2.50)0.531.25 (0.62 to 2.50)0.531.28 (0.64 to 2.56)0.491.23 (0.61 to 2.47)0.57
 Q3>789.69 to ≤1214.911.23 (0.60 to 2.51)0.571.22 (0.60 to 2.50)0.581.21 (0.59 to 2.50)0.611.26 (0.61 to 2.62)0.53
 Q4>1214.912.25 (1.08 to 4.70)0.032.23 (1.07 to 4.68)0.032.14 (1.01 to 4.53)0.052.02 (0.95 to 4.31)0.07
 P trend0.040.050.070.08
 Continuous (log scale; per SD)1.30 (0.98 to 1.71)0.071.29 (0.98 to 1.71)0.071.27 (0.95 to 1.68)0.101.24 (0.93 to 1.66)0.14
NAG/Cr (milliunits/mg)
 Q1≤2.69ReferenceReferenceReferenceReference
 Q2>2.69 to ≤4.551.52 (0.75 to 3.08)0.241.52 (0.75 to 3.09)0.241.44 (0.71 to 2.94)0.311.44 (0.70 to 2.98)0.32
 Q3>4.55 to ≤7.501.41 (0.69 to 2.90)0.351.41 (0.68 to 2.89)0.351.35 (0.65 to 2.78)0.421.31 (0.63 to 2.72)0.47
 Q4>7.502.05 (0.91 to 4.61)0.082.05 (0.91 to 4.62)0.081.89 (0.82 to 4.37)0.141.70 (0.73 to 3.97)0.22
 P trend0.110.120.190.29
 Continuous (log scale; per SD)1.08 (0.82 to 1.42)0.571.08 (0.82 to 1.42)0.561.03 (0.77 to 1.36)0.850.99 (0.75 to 1.31)0.93
NGAL/Cr (ng/mg)
 Q1≤9.38ReferenceReferenceReferenceReference
 Q2>9.38 to ≤18.710.75 (0.37 to 1.50)0.420.75 (0.37 to 1.51)0.420.72 (0.36 to 1.45)0.360.67 (0.33 to 1.35)0.26
 Q3>18.71 to ≤50.752.05 (0.98 to 4.28)0.062.04 (0.97 to 4.27)0.062.02 (0.96 to 4.26)0.061.83 (0.87 to 3.88)0.11
 Q4>50.751.57 (0.67 to 3.64)0.301.56 (0.67 to 3.63)0.301.24 (0.52 to 2.96)0.631.00 (0.40 to 2.45)0.99
 P trend0.100.100.230.46
 Continuous (log scale; per SD)1.31 (0.95 to 1.81)0.101.31 (0.94 to 1.81)0.111.18 (0.83 to 1.66)0.361.09 (0.77 to 1.55)0.63
  • lnUACR, natural log of the urinary albumin-to-creatinine ratio; OR, odds ratio; 95% CI, 95% confidence interval; L-FABP/Cr, urinary liver fatty acid binding protein indexed to urinary creatinine; LOD, limit of detection; KIM-1/Cr, urinary kidney injury molecule 1 indexed to creatinine; Q, quartile; NAG/Cr, urinary N-acetyl-β-d-glucosaminidase indexed to creatinine; NGAL/Cr, urinary neutrophil gelatinase–associated lipocalin indexed to creatinine.

  • a Matching factors incorporated into conditional logistic regression model with no additional covariates.