Table 1.

Characteristic of patients in the study (N=57)

CharacteristicRecovery Group (n=29)Nonrecovery Group (n=28)P Value
Patient characteristics at inclusion
 Age (yr)66 (60–74)70 (61–79)0.22
 Men 15 (52)21 (75)0.10
 Weight (kg)72 (62–83)75 (66–95)0.42
 Body mass index (kg/m2)26 (23–30)26 (23–32)0.74
 SOFA score5 (3–6)8 (4–12)0.01
 SOFA without renal component4 (3–6)7 (2–11)0.08
 SAPS-II score40 (26–47)59 (35–72)0.003
 Mechanical ventilation7 (24)12 (43)0.17
 Mean arterial pressure (mmHg)76 (68–90)75 (67–85)0.68
 NE infusion6 (21)12 (43)0.09
 Dose of NE (μg/kg per minute)0.43 (0.13–0.67)0.37 (0.16–0.79)>0.99
 Lactate (mg/dl)13.5 (9–16.2)18 (13.5–31.5)0.02
 PaO2/FiO2 ratio247 (205–303)239 (145–319)0.61
Reasons for ICU admission0.29
 Severe sepsis/septic shock5 (17)/6(21)2 (7)/10 (36)
 Major surgery11 (38)8 (29)
 Acute respiratory failure5 (17)3 (11)
 Acute hemorrhage1 (3)2 (7)
 Acute pancreatitis1 (3)1 (4)
 Acute liver failure0 (0)2 (7)
Infection source0.81
 Intra-abdominal6 (46)7 (64)
 Pulmonary3 (23)2 (18)
 Mediastinal2 (15)1 (9)
 Biliary2 (15)1 (9)
Prior kidney function
 Baseline creatinine (mg/dl)0.8 (0.6–0.9)0.9 (0.7–1.1)0.02
 eGFR (ml/min per 1.73 m2)a95 (79–99)78 (59–98)0.05
Renal function at inclusion
 Diuresis (ml/h)0.46 (0.33–0.61)0.24 (0.12–0.37)<0.001
 Serum urea (mg/dl)24.6 (15.7–31.9)32.2 (28.3–52.9)0.004
 Serum creatinine (mg/dl)1.2 (0.7–1.5)1.9 (1.3–2.9)<0.001
 KDIGO stage at inclusion<0.001
  17 (24)1 (4)
  220 (69)10 (36)
  32 (7)17 (61)
 Fluid balance (ml)b1910 (1300–2700)2670 (1860–3270)0.04
Evolution
 Maximum KDIGO stage reached<0.001
  16 (21)1 (4)
  221 (72)5 (18)
  32 (7)22 (79)
 RRT0 (0)9 (32)<0.001
 ICU, length of stay (d)6 (4–8)8 (6–20)0.01
 Hospital, length of stay (d)15 (13–25)27 (13–52)0.17
 ICU mortality2 (7)6 (21)0.14
 Hospital mortality2 (7)12 (43)0.004
 Major adverse kidney eventsc2 (7)14 (50)<0.001
  • Data are expressed as medians (interquartile ranges) or n (%). SOFA, Sequential Organ Failure Assessment; SAPS, Simplified Acute Physiology Score; ICU, intensive care unit; KDIGO, Kidney Disease Improving Global Outcomes.

  • a Calculated using the Chronic Kidney Disease Epidemiology Collaboration formula.

  • b Calculated the day of admission.

  • c Major adverse kidney events at hospital discharge truncated at 30 days.