Table 1.

Select transporters involved in organic ion transport in the kidney proximal tubule

NameHGNC Gene SymbolaCommon SymbolAlternative Symbol(s)Other Name
Organic Anion Transporter 1SLC22A6OAT1NKTNovel Kidney Transporter
Organic Anion Transporter 3SLC22A8OAT3ROCTReduced in Osteosclerosis Transporter
Organic Anion Transporter 4SLC22A11OAT4
Urate Anion Exchanger 1SLC22A12URAT1RSTRenal-Specific Transporter
Organic Cation Transporter 2SLC22A2OCT2
Multidrug and Toxin Extrusion Protein 1SLC47A1MATE1
Multidrug Resistance Protein 1ABCB1MDR1P-gpP-glycoprotein
Breast Cancer Resistance ProteinABCG2BCRP
Multidrug Resistance Associated Protein 2ABCC2MRP2
Multidrug Resistance Associated Protein 4ABCC4MRP4
  • a For each solute carrier (SLC), a number (the family series) is followed by the letter A, which serves as a divider, and then the number of the particular transporter within that family; ATP-binding cassette (ABC) nomenclature includes a letter (A–G) to describe the subfamily, and then the number of the transporter member. By convention, transporters are displayed as all uppercase letters when referring to proteins or human genes. HGNC, Human Genome Organisation gene nomenclature committee; OAT, organic anion transporter; URAT1, urate transporter 1; OCT, organic cation transporter; MATE1, multidrug and toxin extrusion protein 1; MDR1, multidrug-resistant protein 1; BCRP, breast cancer resistance protein; MRP, multidrug-associated resistance protein.