Table 2.

Selected pattern sensors relevant in kidney disease

ReceptorMPh Versus DCDiseaseFunctional RoleReference
TLR3/7/9MPhLupus model (MRL-Fas mice)Harmful116
TLR9MPhLupus model (MRL-Fas mice)Harmful117
TLR4DCs and MPhUrinary tract infectionProtective53
NLRP3, inflammasomeDCOxalat-induced AKIHarmful35,87
SIGIRRDCsIRIProtective62
A2ARMPhIRIProtective118
AT1RMPhRenal injury in obesityHarmful84
IL-17RDCs and MPhUUOHarmful85
TREM1MPhUUOHarmful86
uPARMPhUUOAnti-inflammatory but profibrotic119
  • TLR, Toll-like receptor; SIGIRR, single Ig IL-1–related receptor; uPar, urokinase receptor; NLRP3, NACHT, LRR, and PYD domains containing protein 3; A2AR, adenosine 2a receptor; AT1R, type I angiotensin receptor; TREM1, triggering receptor expressed on myeloid cells 1; MPh, macrophage; UUO, unilateral ureteral obstruction; IRI, ischemia reperfusion injury.