Table 3.

False-positive rate of alternative AKI diagnostic criteria versus Kidney Disease Improving Global Outcomes on simulated dataset

ParadigmFalse-Positive Rate at Two TestsFalse-Positive Rate at Four Tests
Total CohortCr<1.5Cr≥1.5Total CohortCr<1.5Cr≥1.5
KDIGO2.0 (2.0 to 2.1)0.4 (0.4 to 0.4)8.2 (7.9 to 8.4)8.0 (7.9 to 8.1)2.0 (1.9 to 2.1)30.5 (30.1 to 30.9)
50% Increase0.0 (0.0 to 0.0)0.0 (0.0 to 0.0)0.0 (0.0 to 0.0)0.1 (0.1 to 0.1)0.2 (0.1 to 0.2)0.0 (0.0 to 0.0)
Fixed baseline2.0 (2.0 to 2.1)0.4 (0.4 to 0.4)8.2 (7.9 to 8.4)4.5 (4.4 to 4.6)1.1 (1.0 to 1.1)17.9 (17.6 to 18.2)
Sustained increase0 (na)0 (na)0 (na)1.4 (1.4 to 1.5)0.1 (0.1 to 0.2)6.1 (5.9 to 6.3)
  • Data are expressed as percentage (95% confidence interval) on the basis of medium laboratory coefficient of variation and biologic variability of 4.4%. Creatinine (Cr) is represented in milligrams per deciliter. KDIGO, Kidney Disease Improving Global Outcomes; na, not applicable.