Table 2.

Sensitivity analyses

Diagnostic CriteriaRationale
50% Increase
 Increase in SCr by ≥50% within prior 7 dExcludes the 0.3-mg/dl criteria, which may be overly sensitive
Fixed baseline
 Increase in SCr by ≥0.3 mg/dl from admission SCr within 48 h or ≥50% from admission SCr within prior 7 dPrevents values lower than a fixed baseline from being taken into account
Sustained increase
 Increase in two respective consecutive SCr by ≥0.3 mg/dl from lowest SCr within 48 h or ≥50% from lowest SCr within prior 7 d, which is sustained for at least one additional consecutive SCr measurementCommensurate with medical guidelines requiring documentation of a condition on more than one instance (e.g., hypertension)
  • Variations of the standard Kidney Disease Improving Global Outcomes (KDIGO) criteria used to evaluate the false-positive rate under different circumstances. The 50% increase simulation defines AKI as a rise in serum creatinine (SCr) by 50% within 7 days, excluding the 0.3-mg/dl criteria included in the Acute Kidney Injury Network and KDIGO definitions of AKI. The fixed baseline simulation ignores all simulated measured SCr values lower than the first value of the hospital stay. The sustained increase simulation requires that two consecutive SCr values be consistent with AKI to confirm the diagnosis.