Table 4.

Comparing clinical outcomes of the reference cohort using Kidney Disease Improving Global Outcomes and alternative AKI diagnostic criteria

ParadigmCaptured Events (% Versus KDIGO)Missed Events (% Versus KDIGO)
KDIGO AKI
 Any AKI 22670
 Higher AKI staging6010
 Inpatient dialysis1950
 Inpatient mortality2250
50% Increase
 Any AKI1553 (68.5)714 (31.5)
 Higher AKI staging579 (96.3)22 (3.7)
 Inpatient dialysis173 (88.7)22 (11.3)
 Inpatient mortality181 (81.5)44 (18.5)
Fixed baseline
 Any AKI1482 (65.4)785 (34.6)
 Higher AKI staging518 (86.2)83 (13.8)
 Inpatient dialysis188 (96.4)7 (3.6)
 Inpatient mortality195 (86.7)30 (13.3)
Sustained increase
 Any AKI1369 (60.4)898 (39.6)
 Higher AKI staging568 (94.5)33 (5.5)
 Inpatient dialysis183 (93.8)12 (6.2)
 Inpatient mortality182 (80.9)43 (19.1)
  • These data represent the number of patients meeting the definition of AKI by the Kidney Disease Improving Global Outcomes (KDIGO), fixed baseline, or sustained increase criteria who experienced the adverse clinical end points of higher AKI staging, inpatient dialysis, and inpatient mortality. The percentage of captured or missed clinical events is stated in parentheses. For example, 195 patients who met the fixed baseline definition of AKI experienced death (86.7% of 225 deceased patients with AKI by KDIGO criteria).