Table 3.

Multivariate analysis: Risk factors for progression to AKI III and hospital mortality

IndicesProgression to AKI IIIHospital Mortality
Odds Ratio 
(95% Confidence Interval)P ValuePercent Retained in Bootstrap AnalysisOdds Ratio 
(95% Confidence Interval)P ValuePercent Retained in Bootstrap Analysis
Mechanical ventilation22.6 (2.37 to 215.0)0.01280.75 (0.56 to 2.18)0.605
CAD/CCF3.32 (1.61 to 6.84)0.001791.21 (0.66 to 2.12)0.5313
Arterial lactate within 12 h of AKI I (per 1 mmol/L)1.53 (1.14 to 2.06)0.004811.19 (0.97 to 1.46)0.1026
SOFA score on the day of AKI I1.18 (1.03 to 1.37)0.02471.17 (1.04 to 1.32)0.0154
CVP (per 2 cm H2O)1.09 (1.02 to 1.16)0.01540.99 (0.94 to 1.04)0.795
DO2I (per 50 ml/min per m2)0.87 (0.77 to 0.98)0.03630.96 (0.86 to 1.06)0.409
MAP 12 h (per 5 mmHg)0.76 (0.59 to 0.98)0.03651.02 (0.83 to 1.26)0.838
Vasopressor use1.49 (0.36 to 6.22)0.5953.92 (1.08 to 14.2)0.0430
Urine output on the day of AKI I (per 100 ml)0.46 (0.20 to 1.07)0.07390.99 (0.98 to 0.99)0.00471
Fluid balance on the day of AKI I (per 1000 ml)1.00 (0.89 to 1.13)0.9981.07 (0.96 to 1.20)0.2226
APACHE II score on admission to the ICU1.04 (0.97 to 1.10)0.28251.05 (0.99 to 1.11)0.0834
  • Multivariate analysis of risk factors identified in univariate analysis using forward stepwise logistic regression. AKI III, stage 3 AKI; CAD, coronary artery disease; CCF, congestive cardiac failure; AKI I, stage 1 AKI; SOFA, Sequential Organ Failure Assessment; CVP, central venous pressure; DO2I, indexed systemic oxygen delivery; MAP, mean arterial blood pressure; APACHE, Acute Physiology and Chronic Health Evaluation; ICU, intensive care unit.