Table 2.

Changes in biomarker concentrations over 3 years in children and young adults with ADPKD

MarkerPlacebo and PravastatinNormal Range in 
Adults and Children
Baseline36 mo
Methionine plasma, µM 18.0±9.320.7±12.533±9 (49)a
14.0±6.020.2±7.332±6 (50)
9-HODE plasma, ng/ml6.3±2.27.1±2.92.0±0.5 (51)a
7.7±5.96.3±2.5
13-HODE plasma, ng/ml8.3±3.011.4±6.33.1±0.4 (51)a
9.9±6.08.8±3.2
8-HETE plasma, pg/ml130±77162±139240±11 (51)a
125±78118±31
11-HETE plasma, pg/ml304±240282±260233±19 (51)a
277±169168±75
12-HETE plasma, ng/ml3.0±4.34.8±9.21.4±0.1 (51)a
1.9±2.41.7±1.2
15-HETE plasma, pg/ml762±531930±806256±70 (51)a
847±497630±181
15-HEPE plasma, pg/ml57.0±27.948.5±22.063±6 (51)a
73.5±42.847.7±15.2
Citrate urine, µM/mmol creatinine207±172158±140203 (49–600) (52)
156±161173±203184 (59–652) (53)
PGF2α urine, ng/mmol creatinine244±208160±134106±17 (54)a
209±287186±165
9-HODE urine, ng/mmol creatinine93.9±56.577.0±42.830.2±28.8
101±11577.9±41.9
13-HODE urine, ng/mmol creatinine200±342131±16961.5±82.5
169±201135±146
8-HETE urine, ng/mmol creatinine20.0±50.813.0±17.815.2±23.3 (55)
14.4±14.519.3±30.516.1±10.9
9-HETE urine, ng/mmol creatinine21.5±66.116.8±15.524.1±17.9
17.7±20.421.3±26.9
11-HETE urine, ng/mmol creatinine14.2±29.97.8±6.917.4±10.2
10.9±9.311.2±18.5
11-HETE urine, ng/mmol creatinine690±3158340±57450.8±63.1
301±523451±739
  • Biomarker concentrations measured in patients with ADPKD are presented as the mean±SD. Normal ranges of biomarker concentrations in healthy adults and children (where available) were adopted from the literature and are presented as the mean±SD, mean±SEM, or mean (25 percentile to 75 percentile). Normal ranges of urinary HODEs and HETEs were determined in house in the spot urine of 15 healthy adult volunteers (10 men and 5 women, also normalized to creatinine). ADPKD, autosomal dominant polycystic kidney disease; HODE, hydroxyoctadecadienoic acid; HETE, hydroxyeicosatetraenoic acid; HEPE, hydroxyeicosapentaenoic acid.

  • a Mean±SEM.