Table 3.

Multivariable models of biopsy results and graft loss

Variable Patients (n)Hazard Ratio (95% Confidence Interval)P Value
Independent effect of C4d scoring resulta,b
 0671Reference
 1391.73 (0.95 to 3.14)0.07
 2542.29 (1.44 to 3.66)<0.001
 3612.72 (1.79 to 4.12)<0.001
Independent effect of number of ABMR lesionsa,c
 0 lesions494Reference
 1 lesion2752.02 (1.45 to 2.79)<0.001
 2 lesions852.63 (1.69 to 4.08)<0.001
 3 or more lesions254.15 (2.32 to 7.44)<0.001
Independent effect of C4d versus ABMR morphologya
 Overall cohort806e
 C4d in PTCsd1.85 (1.34 to 2.57)<0.001
 ABMR morphology1.91 (1.38 to 2.66)<0.001
  • ABMR, antibody-mediated rejection; PTCs, peritubular capillaries.

  • a Confounding variables were selected according to the purposeful selection algorithm as described in the Materials and Methods section (recipient age, donor age, HLA-mismatch, cold ischemia time).

  • b C4d staining in PTCs was scored according to the Banff scheme.

  • c Documented ABMR lesions were glomerulitis (g score >0), peritubular capillaritis (ptc score >0), severe intimal arteritis (v score of 3), thrombotic microangiopathy, and glomerulopathy (cg score >0).

  • d C4d positivity was defined as a C4d score ≥1.

  • e Number of patients for whom all confounding variables included in the model were available.