Table 2.

Relationship between C4d scores and morphologic features suggestive of antibody-mediated rejection

Morphologic resultsaAll Patients (n=874)C4d Score: 0 (n=671)C4d Score: 1 (n=39)C4d Score: 2 (n=54)C4d Score: 3 (n=61)P Value
Individual ABMR lesionsb,c(%)
 Glomerulitis (g)
  g score >01912195058<0.001
  g score: 1545917
  g score: 27462018
  g score: 37482123
 Peritubular capillaritis (ptc)
  ptc score >03126505161<0.001
  ptc score: 11311221923
  ptc score: 21512283025
  ptc score: 3330214
 Transplant glomerulopathy (cg)
  cg score >0129192636<0.001
  cg score: 1548514
  cg score: 2320113
  cg score: 34311919
 Capillary microthrombi9716930<0.001
 Severe intimal arteritis (v3)10.60230.10
Number of different ABMR features (%)
 0 lesions5663332212<0.001
 1 lesion3129594338<0.001
 2 lesions10653234<0.001
 ≥3 lesions 323416<0.001
  • ABMR, antibody-mediated rejection.

  • a For patients with two or more biopsies, for each individual lesion the maximum score documented during follow-up was recorded.

  • b Adequate material for re-evaluation of single criteria suggestive of ABMR was available for 817 (g), 754 (ptc), 846 (capillary microthrombi), 821 (v3), and 801 (cg) patients.

  • c Lesions were scored according to the Banff 2009 scheme (23).