Table 1.

Selected studies of thyroid hormone deficiency and outcomes in dialysis dependent CKD patients

StudyCohort (n)Thyroid MetricOutcome
Cardiovascular surrogates
 Jaroszyński et al. (2005) (9)HD (52)↓ FT3↓ Ventricular depolarization
 Zoccali et al. (2006) (12)HD + PD (234)↓ FT3↓ LV systolic function
↑ LV massb
 Tatar et al. (2011) (11)HD (137)↓ FT3↑ Atherosclerosis
↑ Arterial stiffness
 Meuwese et al. (2013) (10)PD (84)↓ FT3↑ Vascular calcification
Mortality
 Zoccali et al. (2006) (17)HD (200)↓ FT3↑ All-cause mortality
 Ozen et al. (2011) (4)HD (669)↓ FT3↑ All-cause mortalityc
 Meuwese et al. (2012) (13)HD (210)↓TT3 & ↓T4↑ All-cause and CV mortality
 Rhee et al. (2013) (15)HD + PD (2715)↑ TSH↑ All-cause mortality
 Meuwese et al. (2013) (10)PD (84)↓ FT3↑ All-cause mortality
 Drechsler et al. (2014) (20)HD (1000)↓ FT3a↑ All-cause mortality during the first 1 yr of observation
 Rhee et al. (2015) (16)HD (8840)↑ TSH↑ All-cause mortality
  • HD, hemodialysis; PD, peritoneal dialysis; FT3, free triiodothyronine; TT3, total triiodothyronine; T4, thyroxine; TSH, thyrotropin; LV, left ventricular; CV, cardiovascular.

  • a Study found no association between subclinical hypothyroidism (↑TSH + ↓FT4) and mortality.

  • b Attenuated to the null after adjustment for IL-6 and serum albumin.

  • c Attenuated to the null after adjustment for high–sensitivity C–reactive protein and serum albumin.