Table 3.

Comparison of clinical and laboratory features of three drugs associated with drug-induced lupus

DrugClinical FeaturesLaboratory FeaturesPositive Antibody Tests
HydralazineRash, fever, myalgias, pleuritis, polyarthritis nephritis <10%Anemia, leukopeniaANA, anti-dsDNA, ANCA, antihistone
ProcainamidePolyarthritis, polyarthralgias serositis nephritis <10%AnemiaAnti-dsDNA, antihistone, anticardiolipin
TNF-α inhibitorsSystemic symptoms predominant (nephritis in 7%); skin manifestations dominateThrombocytopenia, hypocomplementemiaANA, anti-dsDNA, antinucleosome, anticardiolipin
  • ANA, antinuclear antibody; dsDNA, double-stranded DNA antibody.