Table 4.

Crude and adjusted hazard ratios for ESRD according to glycated hemoglobin tertiles

HbA1c (%)No. of Events/nHR Model 0aHR Model 1bHR Model 2c
Tertiles
 1 (<5.3)58/3091 (ref)1 (ref)1 (ref)
 2 (5.3–5.7)41/3710.61 (0.41 to 0.91)0.60 (0.40 to 0.90)0.67 (0.43 to 1.04)
 3 (5.7–6.5)63/4220.97 (0.68 to 1.38)0.81 (0.57 to 1.17)0.96 (0.65 to 1.43)
P–Wald0.030.050.15
  • The analysis included 1102 patients with CKD stages 1–4 (exclusion of 63 patients with CKD stage 5). HbA1c, glycated hemoglobin; HR, hazard ratio; ref, reference.

  • a Model 0: crude model.

  • b Model 1: stratification for baseline measured GFR levels with 6 classes of measured GFR (15–20, 20–30, 30–40, 40–50, 50–60, >60 ml/min per 1.73 m2).

  • c Model 2: model 1 plus adjustment for age, sex, body mass index (<19, 20–24, 25–29, ≥30), race (black/other), urinary protein/creatinine ratio (log), elevated BP (>140/90 mmHg), history of cardiovascular disease (yes or no), smoking status (current smoker, former smoker, or never smoker), angiotensin-converting enzyme inhibitor or antireceptor blocker treatment, and serum albumin (>3.5 g/dl or <3.5 g/dl).